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CAPN7 Antibody

  • 中文名稱：
    CAPN7兔多克隆抗體
  • 貨號：
    CSB-PA128390
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA128390(CAPN7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human normal liver tissue, mouse liver tissue, mouse intestines tissue, Mouse pancreas tissue, hepg2 cells, HT29 cells, mouse heart tissue, Primary antibody: CSB-PA128390(CAPN7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CAPN7
  • 別名：
    CAPN7 antibody; PALBHCalpain-7 antibody; EC 3.4.22.- antibody; PalB homolog antibody; PalBH antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CAPN7
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease.
  • 基因功能參考文獻(xiàn)：
    1. The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway. PMID: 24953135
    2. Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2. PMID: 23855590
    3. Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity. PMID: 23497113
    4. The detected enhancement of autolysis of mGFP-fused calpain-7 by coexpression with CHMP1B and observed further activation by additional coexpression of IST1 in HEK293T cells. PMID: 21616915
    5. Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. PMID: 20849418

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C2 family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1484

    OMIM: 606400

    KEGG: hsa:23473

    STRING: 9606.ENSP00000253693

    UniGene: Hs.595234