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CASC3 Antibody

  • 中文名稱：
    CASC3兔多克隆抗體
  • 貨號：
    CSB-PA267293
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA267293(CASC3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CASC3
  • 別名：
    Barentsz antibody; Barentsz protein antibody; Btz antibody; Cancer susceptibility candidate 3 antibody; Cancer susceptibility candidate gene 3 protein antibody; CASC3 antibody; CASC3_HUMAN antibody; Metastatic lymph node 51 antibody; Metastatic lymph node gene 51 protein antibody; Metastatic lymph node protein 51 antibody; MLN 51 antibody; MLN 51 protein antibody; MLN51 antibody; Protein barentsz antibody; Protein CASC3 antibody; Protein MLN 51 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CASC3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer.
  • 基因功能參考文獻(xiàn)：
    1. High CASC3 expression is associated with hepatocellular carcinoma. PMID: 27029030
    2. MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor eIF3 PMID: 23530232
    3. MLN51 is a key factor in fibroblast-like synoviocyte hyperplasia of rheumatoid arthritis patients. PMID: 21327427
    4. data demonstrate that metastatic lymph node(MLN)51 protein associates with exon junction complex in the nucleus and remains stably associated with messenger RNA in the cytoplasm PMID: 15166247
    5. MLN51 is recruited into cytoplasmic aggregates known as stress granules (SGs) together with the SG-resident proteins. PMID: 17652158

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  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite.
  • 蛋白家族：
    CASC3 family
  • 組織特異性：
    Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17040

    OMIM: 606504

    KEGG: hsa:22794

    STRING: 9606.ENSP00000264645

    UniGene: Hs.743287