CD83 Antibody
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中文名稱:CD83兔多克隆抗體
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貨號(hào):CSB-PA004962KA01HU
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規(guī)格:¥2640
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:CD83
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別名:CD83; CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Recombinant protein of Human CD83
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Affinity purification
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB,IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
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基因功能參考文獻(xiàn):
- the presence of CD83 in mDC membranes enhances T lymphocyte proliferation by boosting calcium release from intracellular stores in these cells. PMID: 24436459
- this study shows that the tolerogenic mechanism of action of sCD83 to be dependent on initial interaction with antigen-presenting cells, altering early cytokine signal pathways and leading to T cell unresponsiveness PMID: 28193829
- this study shows differential expression and function of CD83 on human immune cells, and reveals potential new roles for this molecule as a target of therapeutic manipulation in transplantation, inflammation, and autoimmune diseases PMID: 27837105
- We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites PMID: 27702941
- Crystal structure of human CD83 reveals that its surface domain consists of an Ig-like domain only.CD83 exerts its immunological activity by mixed homotypic and heterotypic interactions as typically observed for proteins present in the immunological synapse. PMID: 28315353
- this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD83 PMID: 27421624
- Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2. PMID: 26561569
- nonspreading Rift Valley fever virus infection of monocyte-derived immature denditic cells results in incomplete maturation, associated with gradual downregulation of CD83. PMID: 26575844
- Sustained expression of CD83 was observed when CD4+ T cells were induced by transforming growth factor-beta to differentiate into CD4+CD25+ forkhead box P3+ regulatory T (iTreg) cells. PMID: 25997495
- These results suggest that HTLV-I induces CD83 expression on T cells via Tax1 -mediated NF-kappaB activation, which may promote HTLV-I infection in vivo. PMID: 26129803
- CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. PMID: 25151500
- GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation and that this interaction plays a role in CD83 glycosylation as well as in surface expression of CD83 on dendritic cells. PMID: 25701785
- suggesting that a negative feedback regulation may exist in monocyte differentiation into dendritic cells (DCs) based on sCD83 released from the mature DCs PMID: 25243645
- IDO and CD83 are expressed differently in human epidermal Langerhans cells PMID: 24268989
- HSV-1 ICP0 alone induces CD83 degradation independent of its E3 ubiquitin ligase function and of the ubiquitin machinery. PMID: 24643878
- Data indicate that the frequencies of CD11c, CD11c/CD86, HLA-DR/CD86, CD83 and CD80 were significantly high, while CD11c/HLA-DR was low in Hepatitis E infection. PMID: 23246582
- We identified IRF-1, IRF-2, IRF-5, p50, p65, and cRel to be involved in regulating maturation-specific CD83 expression in DCs. PMID: 23339870
- Results do not suggest that the common genetic variation of CD83 is related to cervical or vulvar cancers. The association between tagSNP rs853360 and risk of cervical SCC is likely to be due to chance. PMID: 22134374
- CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2 PMID: 22065790
- Suggest that impaired immune function, absence of CD83-positive mature and activated dendritic cells in cancer nodules may have a role in the pathogenesis of thyroid papillary carcinoma. PMID: 21469977
- No CD83-positive Langerhans cells were detected in any epidermodysplasia verruciformis patients or normal controls. PMID: 19317050
- Human solublee CD83 alone is capable of inducing kidney allograft tolerance in kidney transplantation in mice. PMID: 21076370
- Structure identification of recombinant CD83 mutant variant as a potent therapeutic protein is reported. PMID: 20566323
- sCD83 is capable of attenuating dendritic cell maturation and function, and inducing donor-specific allograft tolerance, in the absence of toxicity. PMID: 20861805
- Data show that pollen grains triggered the production of IL-8, TNF-alpha, IL-6 and strongly upregulated the membrane expression of CD80, CD86, CD83, HLA-DR and caused only a slight increase in the expression of CD40. PMID: 20118277
- Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. PMID: 19257981
- the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83. PMID: 12072358
- cloning and characterization of the promoter region of the human CD83 gene PMID: 12182451
- Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease PMID: 12594843
- induction of the CD83 promoter by LMP1 of Epstein-barr virus is mediated by the activation of NF-kappaB signal pathway in B cells PMID: 12857898
- 20% of chronic lymphocytic leukemia & 5/7 mantle-cell lymphoma patients have significantly elevated levels of soluble CD83. sCD83 may have an immunoregulatory role in vivo & functional significance in hematological malignancies, like CLL and MCL. PMID: 14687618
- infected mature monocyte-derived dendritic cells lose surface CD83 while maintaining intracellular protein expression in cytomegalovirus infection. PMID: 14962896
- monocytes, macrophages and immature DCs contain preformed intracellular CD83, and its rapid surface expression upon activation is post-translationally regulated in a process involving glycosylation PMID: 15320871
- combined treatment of phosphatidic acid and tumor necrosis factor-alpha induce expression of CD83 in KG1 cells. PMID: 15454113
- analysis of monomeric and dimeric isoforms of CD83 PMID: 15721284
- Putative soluble forms of CD83 proteins are characterized by a partial deletion of the extracellular and transmembrane domains; the smallest CD83 splice product shows a strong inhibitory effect on T cell proliferation in mixed leukocyte reactions. PMID: 15905506
- Results suggest the importance of tumor-infiltrating CD83(+) dendritic cells as a useful prognostic factor for patients with gallbladder carcinoma. PMID: 16012714
- The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86 PMID: 17197902
- HSV-1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome PMID: 17428858
- The abundance of CD83+ plasmacytoid dendritic cells (DCs) in perivascular areas and the overexpression of CCL19 and CCL21 in perivascular cellular foci suggest plasmacytoid DCs are central to the muscle inflammation in juvenile dermatomyositis. PMID: 17469160
- CD83 antigen was identified as a useful tumor marker for the diagnosis of pediatric large cell lymphoma. PMID: 17535098
- mRNA can be measured by real-time polymerase chain reaction to determine removal of dendritic cells in whole blood PMID: 17561858
- membrane expression of the dendritic cell maturation marker CD83 on tumor cells from lung cancer patients PMID: 17628801
- CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer PMID: 18056445
- In rheumatoid arthritis patients, the number of CD304(+) plasmacytoid DCs (pDCs) exceeded that of CD1c(+) myeloid DCs (mDCs), with the majority of infiltrating DCs being CD83(-) or DC-LAMP(-). PMID: 18292234
- Data suggest that in systemic lupus erythematosus, the increased number of plasmacytoid dendritic cells (DCs) supports a pathogenic role for these cells, and decreased myeloid DC and CD83 expression may explain susceptibility to infections. PMID: 18625638
- GM-CSF can both synergize with TNFalpha in the case of expression of IL1-RA and antagonize in the case of CD83. PMID: 18755511
- The CK2 alpha' phosphorylates APRIL and therefore is responsible for the regulation of the nucleocytoplasmic translocation of CD83 mRNA. PMID: 19130553
- sCD83 release may play a regulatory role in CLL progression. PMID: 19195701
- Overexpression of CD83 in transgenic mice suppresses the humoral response to both T cell-independent and T-cell dependent model antigens in a dose-dependent manner. PMID: 19234177
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.
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組織特異性:Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.
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