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CDH4 Antibody

  • 中文名稱：
    CDH4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA011058
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CDH4
  • 別名：
    CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human R-cadherin.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
  • 基因功能參考文獻(xiàn)：
    1. Low expression of CDH4 is associated with lung cancer. PMID: 28095912
    2. Further knockdown R-cadherin in linc-cdh4-2 stably overexpressed cells, could significantly upregulate the protein levels of RAC1 and improve the cell migration and invasion abilities. Taken together, the novel linc-cdh4-2 may negatively regulate the motility of the HCC cells through targeting R-cadherin-RAC1 signaling pathway. PMID: 27765630
    3. Data show that low expression of R-cadherin is associated with the poor prognosis in gastric cancer. PMID: 27029387
    4. P-cadherin expression correlated with tumor progression and could be an independent predictor for bladder cancer survival. PMID: 24429027
    5. R-cadherin adherens junction formation facilitates a mesenchymal to epithelial-like transition in MDA-MB-231 cells. PMID: 22820501
    6. Findings identify an important role of CHD4 in controlling homologous recombination repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 deficiency in tumors. PMID: 22219182
    7. a novel putative tumor suppressor gene that can be frequently and tumor-specifically inactivated by its promoter methylation in nasopharyngeal carcinoma PMID: 21665361
    8. R-cadherin induces cell motility when expressed in epithelial cells, and this increased motility is dependent upon Rho GTPase activity. PMID: 15143071
    9. CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis PMID: 15548679

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed mainly in brain but also found in other tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1763

    OMIM: 603006

    KEGG: hsa:1002

    STRING: 9606.ENSP00000353656

    UniGene: Hs.473231