CDON Antibody
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中文名稱:CDON兔多克隆抗體
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貨號(hào):CSB-PA005100GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:CDO antibody; Cdon antibody; CDON_HUMAN antibody; Cell adhesion molecule-related/down-regulated by oncogenes antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human CDON
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
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基因功能參考文獻(xiàn):
- We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
- CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
- These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
- Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
- Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
- We found that CDON is overexpressed in prostate cancer PMID: 21849809
- CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
- Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
- CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
- CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
- Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190
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相關(guān)疾病:Holoprosencephaly 11 (HPE11)
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亞細(xì)胞定位:Cell membrane; Single-pass membrane protein.
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數(shù)據(jù)庫(kù)鏈接:
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