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CEP57 Antibody

  • 中文名稱：
    CEP57兔多克隆抗體
  • 貨號：
    CSB-PA095230
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from LOVO cells and COLO cells, using MRPS7 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CEP57 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CEP57
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CEP57.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.
  • 基因功能參考文獻(xiàn)：
    1. Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 complex/Ndc80 complex) network and spindle assembly checkpoint via Mis12 binding and Mad1-Mad2 interaction. PMID: 26743940
    2. We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter PMID: 26561035
    3. Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
    4. Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
    5. Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. PMID: 23243019
    6. Cep57 acts as a PCM component through binding to NEDD1 and is required for spindle microtubule organization and maintenance of spindle pole integrity. PMID: 22508265
    7. Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division. PMID: 21552266

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  • 相關(guān)疾病：
    Mosaic variegated aneuploidy syndrome 2 (MVA2)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Translokin family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30794

    OMIM: 607951

    KEGG: hsa:9702

    STRING: 9606.ENSP00000317902

    UniGene: Hs.101014