CHRM1 Antibody
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中文名稱:CHRM1兔多克隆抗體
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貨號:CSB-PA005381PA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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Immunofluorescence staining of U251 cells with CSB-PA005381PA01HU at 1:50,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Muscarinic acetylcholine receptor M1 anti-Homo sapiens (Human) CHRM1 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:CHRM1; Muscarinic acetylcholine receptor M1
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宿主:Muscarinic acetylcholine receptor M1
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反應(yīng)種屬:Human
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免疫原:Peptide sequence from Human Muscarinic acetylcholine receptor M1 protein (2-21aa)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,CHRM1 Antibody (CSB-PA005381PA01HU),的標(biāo)記方式是Non-conjugated。對于CHRM1 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Antigen Affinity purified & Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IF
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推薦稀釋比:
Application Recommended Dilution IF 1:50-1:200 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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基因功能參考文獻(xiàn):
- The study was focused on the human mAChR1 receptor for which a presumably reliable model was generated using the congener mAChR3 as the template along with a second less reliable model based on the distant beta2-AR template. The second model was then utilized to produce the chimeras by combining the conformations of its Pro-containing helices (i.e., TM4, TM5, TM6 and TM7 with 16 modeled chimeras). PMID: 27490167
- he discovery of a receptor homolog of human mAChR1 on Acanthamoeba with future studies planned to show its expression and binding to cholinergic agonist and antagonist would help clarify its role in the biology of this protist pathogen. PMID: 27601178
- Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.( PMID: 27834678
- There were no significant associations between CHRM1 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics. PMID: 27923235
- changes in membrane cholesterol concentration differentially impact preferential and non-preferential M1 and M3 receptor signaling PMID: 24821386
- The rs2067477 muscarinic M1 receptor genotype is associated with grey matter volume in schizophrenia. PMID: 26481978
- crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium PMID: 26958838
- this study highlights how the properties of affinity and cooperativity can be differentially modified on a common structural scaffold and identifies molecular features that can be exploited to tailor the development of M1 mAChR-targeting PAMs. PMID: 25326383
- CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients. PMID: 24430298
- the levels were comparable for complexes containing GluR2, GluR3 and GluR4 as well as 5-HT1A. Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 were significantly increased in male patients with AD. PMID: 24292102
- We show that BQCA potentiates agonist-induced beta-arrestin recruitment to M1 mAChRs. PMID: 24753247
- In patients with schizophrenia, both cell body staining and elevated M1 muscarinic receptor reactivity correlated with higher symptom scores. PMID: 24636402
- demonstrate that activation of M1 muscarinic acetylcholine receptor augments the restitution of epithelial barrier function in T84 cell monolayers after ethanol-induced epithelial injury, via ERK-dependent phosphorylation of focal adhesion kinase PMID: 24365239
- Mutation of amino acid residues that form the orthosteric binding pocket caused a loss of carbachol response that could be rescued by BQCA. PMID: 24443568
- Results show that downregulation of cholinergic receptor M1 by histone H3K9me3 impairs calcium signally and contributes to the pathogenesis of Huntington's disease. PMID: 23455440
- Decreased muscarinic M1 receptor radioligand binding is found in the cerebral cortex of schizophrenic patients. PMID: 22338582
- M1-mAChRs function at both surface and intracellular sites in telencephalon neurons including the hippocampus PMID: 23678982
- The fluorescent compounds inherit bitopic properties from a linker-guided positioning of their Bodipy moiety within the M1 allosteric vestibule. PMID: 23604140
- Autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells. PMID: 23460876
- A breakdown in gene promoter methylation control of CHRM1 expression contributes to the global pathophysiology of schizophrenia. PMID: 23423139
- These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved. PMID: 22990911
- Collectively, the results of this study demonstrated that SOD1 could activate a transductional pathway through the involvement of M1 muscarinic receptor. PMID: 23147108
- These data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells. PMID: 22865467
- CHRM1 sequence is associated with alterations in some aspects of executive function. Post-mortem study indicates this is not simply due to altered expression at the mRNA level, suggesting sequence alteration may affect the functionality of the CHRM1. PMID: 22391213
- Here we found that M1 Muscarinic acetylcholine receptor (M1 mAChR), an important G protein-coupled receptor involved in cholinergic neuronal activity, can interact with BACE1 and mediate its proteosomal degradation. PMID: 22450048
- The binding mode of MT7 and human muscarinic acetylcholine receptor 1 consists of three interaction regions in five residue interaction clusters. PMID: 22571431
- Binding properties of human muscarinic M1 receptor in stably transfected Chinese hamster ovary cells is significantly enhanced after supplementation, probably by facilitating receptor-mediated G protein activation. PMID: 22146060
- docking calculations structurally support the high affinity and selectivity of the MT7-human M1 muscarinic receptor interaction and highlight the atypical mode of interaction of this allosteric ligand on its G protein-coupled receptor target. PMID: 21685390
- analysis of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor PMID: 21203415
- Distribution of M1 receptors in human colon. PMID: 20146726
- M1 receptor plays an important role in the maintenance of function of retinal pigment epithelium. PMID: 17415969
- Data show that two-color TIRFM established the dynamic nature of dimer formation with M(1) receptors undergoing interconversion between monomers and dimers on the timescale of seconds. PMID: 20133736
- increased inattention scores (Conners' teacher-rating scale) and lower l-MR associated with increased score for oppositional-defiant disorder. PMID: 19863190
- This study demonistred that in subgroup of subjects with schizophrenia decreased cortical muscarinic acetylcholine receptor M1. PMID: 18317461
- Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells. PMID: 19927300
- Fifteen single nucleotide polymorphisms (SNPs) of CHRM1 have been discovered, 9 of which are located in the coding region of the receptor; of these, 8 represent synonymous SNPs, indicating that CHRM1 is highly conserved in humans. PMID: 12049494
- 28% decrease in post-mortem levels of steady-state cortical muscarinic 1 receptor cDNA in schizophrenia patient samples relative to controls PMID: 12707929
- role of M1 and M2 muscarinic receptors expressed by human L cells in the control of GLP-1 secretion. PMID: 12810581
- In conclusion, autoantibodies to CHRM1 were detected in a large number of CFS patients and were related to CFS symptoms. PMID: 12851722
- M1- and M3- but not M2- or M4-AchR signals activate HIF-1 by both stabilization and synthesis of HIF-1alpha and by inducing the transcriptional activity of HIF-1alpha. PMID: 15280370
- mRNA of muscarinic acetylcholine receptor-1 is expressed in human scleral fibroblasts. PMID: 16318751
- All three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho. PMID: 16328454
- Increased phosphorylation of M1 and M2 mAChRs underlies sequestration of these receptors after transient hypoxia. Distinct pathways involving CK1alpha and GRK2 mediated sequestration of M1 and M2 mAChRs after transient hypoxic-induced oxidative stress. PMID: 16336219
- Data demonstrate that M(1), M(2), and M(3) muscarinic acetylcholine receptors (mAChR)can form homo- and heterodimers in living cells, and suggest that heterodimerization plays a role in the mechanism of mAChR long term regulation. PMID: 16368694
- Data show that intracellular zinc uptake in SK-SH-SY5Y cells is controlled by M1-mAChR mediated signalling pathways and that zinc may act as a cofactor for transcriptional regulation of zinc finger genes such as PNUTS. PMID: 16406470
- MT7 toxin interacts with hM1 receptor at a specific allosteric site, which may partially overlap those identified previously for "classic" or "atypical" allosteric agents. PMID: 16439611
- Association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. PMID: 16874522
- mAChR subtypes (m1 to m5) presents in human scleral fibroblasts at both mRNA and protein levels. PMID: 16877267
- This study provides the structural insight for improved understanding of M1 receptor and its binding sites. PMID: 16902941
- Gene Coding the human cholinergic receptor muscarinic-1 is an important susceptibility locus for asthma at chromosome 11q13. PMID: 16931638
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM1 sub-subfamily
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