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  4. CIR1 Antibody

CIR1 Antibody

  • 中文名稱：
    CIR1兔多克隆抗體
  • 貨號：
    CSB-PA773051DSR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: TMOD1 antibody at 2.84μg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 24 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA773051DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA773051DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品評價

靶點詳情

  • 功能：
    May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
  • 基因功能參考文獻：
    1. three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
    2. identified as a PAP-1 binding protein and as a splicing factor PMID: 15652350
  • 亞細胞定位：
    Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
  • 組織特異性：
    Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24217

    OMIM: 605228

    KEGG: hsa:9541

    STRING: 9606.ENSP00000339723

    UniGene: Hs.632531