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CLCN6 Antibody

  • 中文名稱：
    CLCN6兔多克隆抗體
  • 貨號：
    CSB-PA005485LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • IHC image of CSB-PA005485LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of U251 cells with CSB-PA005485LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CLCN6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLCN6
  • 別名：
    Chloride channel 6 antibody; Chloride channel protein 6 antibody; Chloride channel voltage sensitive 6 antibody; Chloride transport protein 6 antibody; ClC 6 antibody; ClC-6 antibody; ClC6 antibody; CLCN6 antibody; CLCN6_HUMAN antibody; KIAA0046 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Chloride transport protein 6 protein (572-869AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CLCN6 Antibody (CSB-PA005485LA01HU)，的標(biāo)記方式是Non-conjugated。對于CLCN6 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA005485LB01HU CLCN6 Antibody, HRP conjugated ELISA
    FITC CSB-PA005485LC01HU CLCN6 Antibody, FITC conjugated
    Biotin CSB-PA005485LD01HU CLCN6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
  • 基因功能參考文獻(xiàn)：
    1. These findings implicate the effect of rare coding variants in CLCN6 in Blood Pressure variation and offer new insights into Blood Pressure regulation. PMID: 26658788
    2. A non-synonymous single nucleotide variation (SNV) was identified in the voltage-sensitive chloride channel 6 gene. PMID: 25794116
    3. late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression PMID: 20466723
    4. differential sorting of endogenous (late endosomal) versus overexpressed (early and recycling endosomal) ClC-6 is reminiscent of that of other late endosomal/lysosomal membrane proteins PMID: 17534424
  • 亞細(xì)胞定位：
    Endosome membrane; Multi-pass membrane protein. Note=Detected in detergent-resistant lipid rafts.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-6/CLCN6 subfamily
  • 組織特異性：
    Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2024

    OMIM: 602726

    KEGG: hsa:1185

    STRING: 9606.ENSP00000234488

    UniGene: Hs.193043