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CLEC10A Antibody

  • 中文名稱：
    CLEC10A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA945457
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA945457(CLEC10A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLEC10A
  • 別名：
    C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 13 (macrophage derived) antibody; C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 14 (macrophage derived) antibody; C type lectin domain family 10; member A antibody; C type lectin superfamily member 14 antibody; C-type lectin domain family 10 member A antibody; C-type lectin superfamily member 14 antibody; CD301 antibody; CD301 antigen antibody; CD301A antibody; CLC10_HUMAN antibody; CLEC10A antibody; CLECSF13 antibody; CLECSF14 antibody; HML antibody; HML2 antibody; Lectin antibody; Macrophage C type lectin antibody; MACROPHAGE GALACTOSE-TYPE C-TYPE antibody; Macrophage lectin 2 (calcium dependent) antibody; Macrophage lectin 2 antibody; MGL antibody; Mgl1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human CLEC10A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
  • 基因功能參考文獻(xiàn)：
    1. this paper shows that key gene of intermediate proinflammatory monocytes, such as CLEC10A, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
    2. BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms. PMID: 26172302
    3. These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines. PMID: 26147970
    4. expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL. PMID: 23918927
    5. MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 mRNA levels & enhanced TNF-alpha mRNA stability. It promoted phosphorylation of the ERK & CREB, fine-tuning the DC maturation phenotype. PMID: 23744646
    6. Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues. PMID: 23275449
    7. MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8(+) T-cell activation. PMID: 22531918

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16916

    OMIM: 605999

    KEGG: hsa:10462

    STRING: 9606.ENSP00000254868

    UniGene: Hs.54403