Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COL4A6 Antibody

COL4A6 Antibody

  • 中文名稱：
    COL4A6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005747GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    COL4A6Collagen alpha-6(IV) chain antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human COL4A6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
  • 基因功能參考文獻(xiàn)：
    1. Mutation in COL4A6 gene is associated with gastric cancer peritoneal carcinomatosis. PMID: 26811494
    2. COL4A6 is associated with X-linked nonsyndromic hearing loss. PMID: 23714752
    3. We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer. PMID: 23621580
    4. expression of collagen type IV alpha6 chain in the smooth muscle BM of the gastrointestinal tract is restricted to the esophagus in humans PMID: 20951201
    5. The expression of collagen type IV was significantly decreased in colorectal cancer tissues. PMID: 18782525
    6. Enhanced expression of collagen type IV is associated with liver metastases from gastrointestinal tumours PMID: 15679046
    7. This study showed that in some cases of esophageal squamous cell carcinoma the alpha5/alpha6 (IV) chains are expressed linearly around the cancer cell nests and the alpha5/alpha6 (IV) chain expression is one prognostic factor of ESCC. PMID: 17955302
    8. Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6NC1) is an endogenous inhibitor of angiogenesis and tumor growth. PMID: 18074349
    9. Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix. PMID: 18474427

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Deafness, X-linked, 6 (DFNX6)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 蛋白家族：
    Type IV collagen family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2208

    OMIM: 300914

    KEGG: hsa:1288

    STRING: 9606.ENSP00000361290

    UniGene: Hs.145586