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COPZ1 Antibody

  • 中文名稱：
    COPZ1兔多克隆抗體
  • 貨號：
    CSB-PA001759
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of COS7 cells using COP ζ1 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    COPZ1
  • 別名：
    COPZ1 antibody; COPZ antibody; CGI-120 antibody; HSPC181Coatomer subunit zeta-1 antibody; Zeta-1-coat protein antibody; Zeta-1 COP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human COP ζ1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
  • 基因功能參考文獻：
    1. siRNA-mediated COPZ1 depletion causes abortive autophagy, endoplasmic reticulum stress, unfolded protein response and apoptosis in thyroid tumor cells. PMID: 28951131
    2. The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells. PMID: 21746916
  • 亞細胞定位：
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Adaptor complexes small subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2243

    OMIM: 615472

    KEGG: hsa:22818

    STRING: 9606.ENSP00000262061

    UniGene: Hs.505652