DAB1 Antibody
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中文名稱:DAB1兔多克隆抗體
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貨號(hào):CSB-PA002060
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:DAB1
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別名:Dab 1 antibody; Dab reelin signal transducer 1 antibody; Dab; reelin signal transducer; homolog 1 (Drosophila) antibody; Dab1 antibody; DAB1_HUMAN antibody; Disabled homolog 1 antibody; Disabled homolog 1 Drosophila antibody; Scm antibody; Scr antibody; Scrambler antibody; Yot antibody; Yotari antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from Human Dab1 around the non-phosphorylation site of Y232.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, IF, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Adapter molecule functioning in neural development. May regulate SIAH1 activity.
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基因功能參考文獻(xiàn):
- In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location. PMID: 29470947
- these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration. PMID: 28686858
- Study shows that early neural cells transiently express Reelin at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin. PMID: 26270645
- this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations PMID: 26028559
- results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS. PMID: 24844606
- The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent. PMID: 23333377
- Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined. PMID: 22419519
- show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling PMID: 22394407
- alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species PMID: 22163036
- we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients PMID: 21453247
- Dab1, an essential component of the reelin pathway, is required for glia-independent somal translocation in the neocortex. PMID: 21315259
- Fe65 and Dab1 compete for binding to APP. Dab1 significantly decreased the amount of APP bound to LRP and the level of secreted APP and APP-CTF in LRP expressing cells PMID: 20568118
- Thus, the present observations suggest a correlation between Dab1 phosphorylation, Abeta deposition and PrP(sc) type in sCJD. PMID: 19853035
- This gene, is an intracellular adaptor of the Reelin pathway and reveals unusual complexity in human and mouse. PMID: 12446734
- involvement of disabled homolog 1 in neurogenesis PMID: 12581169
- RELN and DAB1 coexpression in these neurons is necessary for both normal cortical development and mature function. PMID: 12834112
- Dab1 immunoreactivity is found in certain populations of amacrine cells of the retina, with lobular appendages in the outer half of the inner plexiform layer (IPL) and a bushy, smooth dendritic tree in the inner half of the IPL. PMID: 14961563
- significantly lower levels of disabled homolog 1 gene transcripts were detected in gangliogliomas compared to controls PMID: 15175076
- Dab1 regulates both cell surface expression and internalization of Reelin receptors PMID: 15718228
- phosphoinositide-binding region within Dab1 PTB domain is required for membrane localization and basal tyrosine phosphorylation of Dab1 PMID: 15883038
- After Reelin binds to the receptors, Disabled-1 becomes phosphorylated on tyrosine residues, initiating a signaling cascade that includes activation of Src-family kinases and Akt. PMID: 16481437
- The effect of Dab1 on APP and apoEr2 processing in transfected cells and primary neurons is reported. PMID: 16951405
- DAB1 phosphorylation occurs solely in the segment spanning the 5th and 6th reelin repeats. PMID: 17548821
- Cul5 plays an essential role in regulating neuron migrations during cortical development, possibly by opposing a promigratory effect of Dab1. PMID: 17974915
- Resides within an unstable common fragile site region and might play a role in human tumorigenesis. PMID: 18008369
- Fyn, due in part to its effects on Dab1, regulates the phosphorylation, trafficking, and processing of APP and apoEr2. PMID: 18089558
- ligation of ApoER2 by APC signals via Dab1 phosphorylation and subsequent activation of PI3K and Akt and inactivation of GSK3beta, thereby contributing to APC's beneficial effects on cells. PMID: 19116273
- results suggest that the mouse ortholog is a nucleocytoplasmic shuttling protein PMID: 17062576
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相關(guān)疾病:Spinocerebellar ataxia 37 (SCA37)
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組織特異性:Mainly expressed in brain.
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