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DBF4B Antibody

  • 中文名稱：
    DBF4B兔多克隆抗體
  • 貨號：
    CSB-PA822784LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: DBF4B antibody at 4µg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 68, 48, 55, 19 kDa
      Observed band size: 48 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA822784LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DBF4B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DBF4B
  • 別名：
    Activator of S phase kinase like protein 1 antibody; Activator of S phase kinase-like protein 1 antibody; ASK like protein 1 antibody; ASK-like protein 1 antibody; ASKL1 antibody; chifb antibody; Chiffon homolog B antibody; DBF 4B antibody; DBF4 homolog B (S. cerevisiae) antibody; DBF4 homolog B antibody; Dbf4 related factor 1 antibody; Dbf4-related factor 1 antibody; dbf4b antibody; DBF4B_HUMAN antibody; DRF1 antibody; FLJ13087 antibody; MGC15009 antibody; Protein DBF4 homolog B antibody; ZDBF1B antibody; Zinc finger DBF type containing 1B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein DBF4 homolog B protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DBF4B Antibody (CSB-PA822784LA01HU)，的標記方式是Non-conjugated。對于DBF4B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA822784LB01HU DBF4B Antibody, HRP conjugated ELISA
    FITC CSB-PA822784LC01HU DBF4B Antibody, FITC conjugated
    Biotin CSB-PA822784LD01HU DBF4B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
  • 基因功能參考文獻：
    1. Knockdown of the exon6-containing isoform (DBF4B-FL) significantly inhibits the tumorigenic potential of colon cancer. Overexpression of DBF4B-FL protects against DNA damage induced by SRSF1 knockdown. PMID: 29262322
    2. Results describe a novel human protein, Drf1, related to both human and yeast Dbf4. Drf1 is a nuclear cell cycle-regulated protein which binds to Cdc7 and activates the kinase. PMID: 12065429
    3. ASKL1 in a complex with Cdc7 may play a role in normal progression of both S and M phases PMID: 15668232
    4. These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling. PMID: 19111665
  • 亞細胞定位：
    Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
  • 組織特異性：
    Widely expressed. Highly expressed in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17883

    OMIM: 611661

    KEGG: hsa:80174

    STRING: 9606.ENSP00000323663

    UniGene: Hs.369998