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  • 中文名稱:
    DBH兔多克隆抗體
  • 貨號:
    CSB-PA020742
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA020742(DBH Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA020742(DBH Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, A172 cells, Hela cells, Primary antibody: CSB-PA020742(DBH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DBH
  • 別名:
    dbh antibody; DBM antibody; Dopamine beta hydroxylase antibody; Dopamine beta monooxygenase antibody; Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody; Dopamine beta-monooxygenase antibody; DOPO_HUMAN antibody; OTTHUMP00000022501 antibody; Soluble dopamine beta-hydroxylase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human DBH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:200-1:1000
    IHC 1:100-1:300
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能:
    Conversion of dopamine to noradrenaline.
  • 基因功能參考文獻:
    1. Most DBH polymorphisms from the currently available loci showed no linkage to Alzheimer's disease, Parkinson's disease, and schizophrenia, indicating the lower possibility of these loci serving as genetic markers of the risks of diseases with neurodegenerative characteristics. On the other hand, the DBH rs2283123 and rs2007153 polymorphisms could have opposite effects on schizophrenia development in Caucasians PMID: 30453293
    2. The findings of this study confirmed a strong association between genotype at rs1611115 and pDbetaH activity in Chinese patients with schizophrenia. Our data also suggest the rs1108580 polymorphism may influence some aspects of cognitive function in schizophrenia. PMID: 28647493
    3. Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults PMID: 29525179
    4. This study demonstrate the genetic influence of a family history of alcohol use disorders and DAT and DBH gene polymorphisms on the risk of withdrawal seizures and delirium tremens. PMID: 28139629
    5. Homospecific activity computed for the WT of DBH and variant proteins showed a marginal decrease in A318S, W544S and R549C variants PMID: 28707163
    6. This study indicated that DBH5'-Ins/Del polymorphism may not play a role in the susceptibility to tardive dyskinesia and cognitive deficits in schizophrenia with tardive dyskinesia. PMID: 27776953
    7. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. PMID: 27447243
    8. Results suggest that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype. PMID: 26667034
    9. Dopamine beta-Hydroxylase Deficiency is associated with Hyperinsulinemia and Insulin Resistance. PMID: 27778639
    10. Dopamin Beta Hydroxylase gene +1603C > T polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population. PMID: 26868704
    11. The genotype and allele distribution frequencies in rs1611115 were different between Parkinson's disease patients and the healthy control. The TT genotype may lead to a 2.95 times higher risk of Parkinson's disease occurrence compared with the common genotype CC. DBH rs1611115 polymorphism was likely to be associated with the susceptibility to PD, but we did not find that rs732833 is a susceptibility marker PMID: 27177268
    12. Results suggest that the DBH gene may play an important role in the occurrence of schizophrenia (SCZ). Also, rs1611114 may be associated with SCZ susceptibility and related clinical symptoms in the Chinese Zhuang but not Han Chinese population. PMID: 27236774
    13. Study found that the functional T allele in DBH SNP rs1611115, which reduces the conversion of dopamine to norepinephrine, corresponds with different BOLD-signal changes in responses to gambling, drug or sad cues in individuals with and without pathological gambling PMID: 27194378
    14. This study demonstrated that the association between DbetaH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents. PMID: 26616837
    15. We report the crystal structure of human dopamine b-hydroxylase, which is the enzyme converting dopamine to norepinephrine. The structure of the DOMON (dopamine b-monooxygenase N-terminal) domain, also found in 1600 other proteins, reveals a possible metal-binding site and a ligand-binding pocket PMID: 27152332
    16. The p.Val26Met variant in the dopamine beta-hydroxylase gene at 9q34.2 was associated with Lung Cancer. PMID: 26762739
    17. A DBH gene variant, rs129882, which confers risk to attention deficit hyperactivity disorder, is also associated with reduced in vitro gene expression. PMID: 25975715
    18. No significant association was found between the DbetaH 5'-Ins/Del polymorphism and patients with chronic schizophrenia. PMID: 26891013
    19. This study finding significant excess of rare nonsynonymous variants exclusive to European Americans smokers in DBH. PMID: 25450229
    20. did not find a significant association of rs1611115 with PTSD risk [meta-analysis] PMID: 26986136
    21. Reported is the construction of a tissue engineered intervertebral disc with high biological activity using an allogeneic intervertebral disc supplemented with transfected nucleus pulposus cells expressing exogenous dopamine beta-hydroxylase. PMID: 26400296
    22. There was no significant relationship between Migraine susceptibility and genetic polymorphisms of DBH. PMID: 26632697
    23. Results suggest that the DBH5'-Ins/Del polymorphism may not contribute directly to the development of tardive dyskinesia in schizophrenia, but it may be involved in the excited behavior of tardive dyskinesia patients PMID: 25336319
    24. C-1021T polymorphism not associated with orthostatic hypotensive risk in a Chinese population PMID: 24990418
    25. this study shows the influence of 444 G/A (rs 1108580) and -1021 C/T (rs 1611115) polymorphisms of the dopamine beta-hydroxylase (DBH) gene on clinical parameters of the trajectory of alcohol dependence. PMID: 26356164
    26. Identification of DBH variants with strong effects makes it possible to take advantage of Mendelian randomization approaches to test causal effects of this intermediate trait on disease. PMID: 24986918
    27. DBH5'-Ins/Del and -1021C/T polymorphism in promoter region of DBH gene was associated with major depressive disorder. PMID: 24888991
    28. The genetic polymorphism in dopamine beta-hydroxylase is associated with methamphetamine-induced paranoia and influences smoking initiation. PMID: 24521142
    29. This study demonstrated the importance of DBH -1021C/T as a genetic basis of empathy and in predicting individual differences in social and affective processing. PMID: 23988761
    30. Demonstrate profound effects of DBH variants on expression in 2 sympathetically innervated organs, liver and lung, and association of these variants with clinical phenotypes responsive to peripheral sympathetic tone. PMID: 25326128
    31. An association between dopamine-beta hydroxylase (DBH) promoter polymorphisms (a 5'-ins/del and a GTn repeats) and a history of suicide attempt in 223 chronic schizophrenia individuals, was studied. PMID: 24710129
    32. This study demonistrated that the Polymorphisms of dopamine beta hydroxylase is not not associated with Alzheimer's disease. PMID: 24201835
    33. Individuals with the normal DbetaH activity genotype (CC) showed no differential response to levodopa treatment for cocaine dependence PMID: 24809448
    34. role for DBH promoter variation in long-term renal decline rate PMID: 24391727
    35. Data suggest that the interaction of single nucleotide polymorphism (SNP) of interleukin-10 (IL-10) and and dopamine beta-hydroxylase (DBH) may play a role in the general symptoms on PANSS in schizophrenic patients with Tardive dyskinesia (TD). PMID: 23951054
    36. This study show DBH5'-ins/del heterozygotes (associated with average level of plasma DbetaH activity) showed increased post-error slowing compared to del/del homozygotes and ins/ins homozygotes (associated with low and high level of plasma DbetaH activity. PMID: 23962674
    37. This study presents evidence for a potentially functional DBH variant influencing the risk for alcohol dependence while other comorbid conditions are not independently influenced PMID: 23906995
    38. These results suggested that dopamine beta hydroxylase gene (DBH) might be related to attention-deficit hyperactivity disorder (ADHD)symptoms in korean children. PMID: 23692268
    39. This study identified that the DBH5'-Ins/Del polymorphism may contribute to the susceptibility to first-episode schizophrenic patients. PMID: 23707643
    40. genetic association studies in the Netherlands: Data suggest that an SNP in DBH (rs2519152) is associated with attention deficit disorder with hyperactivity (but not substance abuse disorders). [PILOT STUDY] PMID: 22841130
    41. although the DBH 5'-Ins/Del polymorphism was not associated with susceptibility to TD in patients with schizophrenia, it might be related to positive symptoms of schizophrenia PMID: 23559427
    42. This study showed genotypes-independent decrease in pDBH activity in patients with AD compared to enzyme activity in age-matched healthy controls. We did not confirm the association of low activity T allele variant of the DBH C-970T and alzheimer disease. PMID: 23416088
    43. the dopamine beta-hydroxylase (DBH) polymorphism (DBH -1021C/T) that is associated with low DbetaH levels also was associated with greater improvement in cocaine positive urines in the vaccine-treated group. PMID: 23458673
    44. -1021TT genotype may be implicated with a more progressive nature of heroin addiction, although DBH -1021C/T is unlikely to be involved in the risk of heroin addiction. PMID: 23510745
    45. DBH rs7239728 imparted significant migraine risk at genotypic, allelic & carrier analyses. 2 genotype interactions between ANKK1 rs1800497 & DBH rs72393728 polymorphisms showed significant risks. PMID: 22875483
    46. DBH and MAOA can influence human attentional biases, and there is a gene-gene interaction between the DBH and MAOA on attentional bias for negative expressions. PMID: 23054588
    47. the DBH genotype of a patient could be used to identify a subset of individuals for which disulfiram treatment might be an effective pharmacotherapy for cocaine dependence. PMID: 22906516
    48. The 1603C>T polymorphism of the DBH gene is associated with susceptibility to bipolar disorder in a Turkish population. PMID: 23384717
    49. The distribution of AA genotype and A allele frequencies of rs5320 in the dopamine beta-hydroxylase gene in ADHD children differed significantly from that in healthy controls. PMID: 22895683
    50. These results suggest that the DBH 5'-Ins/Del polymorphism may influence smoking severity among schizophrenic smokers. PMID: 22871345

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  • 相關疾?。?/div>
    Dopamine beta-hydroxylase deficiency (DBH deficiency)
  • 亞細胞定位:
    [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.; Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Copper type II ascorbate-dependent monooxygenase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2689

    OMIM: 223360

    KEGG: hsa:1621

    STRING: 9606.ENSP00000376776

    UniGene: Hs.591890