DCBLD2 Antibody
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中文名稱:DCBLD2兔多克隆抗體
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貨號:CSB-PA006535GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:DCBLD2
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別名:1700055P21Rik antibody; AW146002 antibody; CLCP1 antibody; coagulation factor V/VIII-homology domains protein 1 antibody; CUB and LCCL domain-containing protein 2 antibody; CUB antibody; CUB; LCCL and coagulation factor V/VIII-homology domains protein 1 antibody; DCBD2_HUMAN antibody; DCBLD2 antibody; Discoidin antibody; discoidin CUB and LCCL domain containing 2 antibody; Discoidin; CUB and LCCL domain-containing protein 2 antibody; Endothelial and smooth muscle cell-derived neuropilin-like protein antibody; ESDN antibody; LCCL and coagulation factor V/VIII-homology domains protein 1 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human DCBLD2
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶點(diǎn)詳情
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基因功能參考文獻(xiàn):
- Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2. PMID: 29025973
- DCBLD2 protein expression profiles were compared between 11 invasive and non-invasive myxofibrosarcomas. Higher DCBLD2 expression was significantly associated with invasive properties of tumor cells. The expression level of DCBLD2 was consistent in different portions of tumor tissues. PMID: 28668639
- phosphorylation of DCBLD2 Y750 recruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of AKT, thereby enhancing EGFR-driven tumorigenesis PMID: 25061874
- ESDN associates with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine phosphatases PTP1B and TC-PTP, and VE-cadherin. PMID: 24177422
- SFK activity was shown to be sufficient, but not required for the interaction between ESDN and the CrkL-SH2 domain PMID: 23770091
- ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
- These findings suggest that DCBLD2 could be a potential marker and drug target for treatment of nasal polyposis in Korean asthma patients. PMID: 22261696
- Seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD. PMID: 22468095
- The full-length signal peptides of DCBLD2 is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
- our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516
- ESDN expression was significantly higher in proliferating, as compared to growth-arrested cells. ESDN overexpression in VSMC led to a decline in growth curves, while ESDN knock down had the opposite effect. PMID: 17697260
- These data suggest that down-regulation of DCBLD2, often associated with promoter hypermethylation, is a frequent event that may be related to the development of gastric cancer. PMID: 18314483
- ESDN modulates PDGF signaling in VSMCs via regulation of PDGFR beta surface levels. PMID: 19696027
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.
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組織特異性:Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.
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