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DIO3 Antibody

  • 中文名稱：
    DIO3兔多克隆抗體
  • 貨號：
    CSB-PA344617LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunofluorescent analysis of PC-3 cells using CSB-PA344617LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DIO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DIO3
  • 別名：
    5DIII antibody; D3 antibody; Deiodinase iodothyronine type 3 antibody; Deiodinase iodothyronine type III antibody; Dio 3 antibody; Dio3 antibody; DIOIII antibody; IOD3_HUMAN antibody; Iodothyronine deiodinase placental type antibody; MGC124117 antibody; MGC124118 antibody; Thyroxine deiodinase type III antibody; Thyroxine deiodinase type III (selenoprotein) antibody; TXDI3 antibody; Type 3 DI antibody; Type 3 iodothyronine selenodeiodinase antibody; Type III 5' deiodinase antibody; Type III iodothyronine deiodinase antibody; Type-III 5''-deiodinase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Thyroxine 5-deiodinase protein (50-115AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DIO3 Antibody (CSB-PA344617LA01HU)，的標記方式是Non-conjugated。對于DIO3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA344617LB01HU DIO3 Antibody, HRP conjugated ELISA
    FITC CSB-PA344617LC01HU DIO3 Antibody, FITC conjugated
    Biotin CSB-PA344617LD01HU DIO3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
  • 基因功能參考文獻：
    1. The expression of DIO3 on mRNA/protein levels in the depressive disorders patients was increased in comparison to the control subjects. PMID: 29182613
    2. The expression of piRNAs encoded at DLK1-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome. PMID: 27829231
    3. A critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential. PMID: 29186449
    4. In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele. PMID: 27329732
    5. Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase system or through modulation of intracellular Thyroid hormone bioavailability. PMID: 27355490
    6. MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma PMID: 26825960
    7. D3 is a critical factor in testis development and in testicular protection from thyrotoxicosis. PMID: 26727108
    8. the microRNA cluster at the Dlk1-Dio3 locus is upregulated in lung adenocarcinoma PMID: 24317514
    9. [review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone parameters. PMID: 24878678
    10. Overall, the data suggest that active expression of the DLK1-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs. PMID: 24123616
    11. the imprinted DLK1-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome PMID: 24816254
    12. Data indicate that Na+/I- symporter and type 3 iodothyronine deiodinase genes are expressed in term placenta and amniotic membrane. PMID: 23857380
    13. Treatment with high affinity amyloidbeta42 oligomer-binding enantiomeric D3 peptide significantly decreases amyloidbeta deposits and the associated inflammatory response and improves cognition, even when applied only at late stages and high age. PMID: 23271316
    14. D3 expression is re-activated in various types of human cancers. It may play a role in carcinogenesis and neoplastic cell proliferation. Review. PMID: 23235188
    15. Reviewed are the microRNAs within the DLK1-DIO3 genomic region, their role in controlling tissue homeostasis and in the pathogenesis of some human diseases, mostly cancer, when aberrantly expressed. [review] PMID: 22825660
    16. Deiodinase iodothyronine type III activity was increased in all papillary thyroid carcinomas as compared with that in adjacent thyroid tissue, parallel with ~ 5 times increase in deiodinase iodothyronine type III mRNA levels. PMID: 22823995
    17. D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone, the absence of which leads to impaired beta-cell function and subsequently insulin secretion and glucose homeostasis PMID: 21828183
    18. coordinate up-regulation of the DLK1-DIO3 miRNA cluster at 14q32.2 may define a novel molecular (stem cell-like) subtype of hepatocellular carcinoma associated with poor prognosis PMID: 21737452
    19. [review] progress made in understanding the physiological function and significance of D3; summarizes the intriguing evidence that D3 plays a pivotal role in defining local TH concentration in the developing fetus and in several conditions in adult life. PMID: 21398344
    20. The minor allele of the DIO3 variant rs945006 showed suggestive evidence for protective association in the overall meta-analyses, which was supported by individual osteoarthritis studies and osteoarthritis subtypes. PMID: 20724312
    21. In this case-control study, homozygosity for type 2 deiodinase Thr92Ala polymorphism is associated with increased risk for type 2 diabetes. PMID: 20566590
    22. The expression of D3 mRNA was more than 10 times higher in the tumor tissue than the mean of placental tissues PMID: 19548001
    23. study demonstrates that D3 is located in the plasma membrane with most of its molecule in the extracellular space, allowing access to inactivate both the hormone T3 and prohormone T4 PMID: 12419801
    24. the SeC residue in the catalytic center of D3 is essential for efficient inner-ring deiodination of T(3) and in particular T(4) at physiological substrate concentrations. PMID: 12746313
    25. D3 contains a glycoside hydrolase clan GH-A-like structure PMID: 12847093
    26. identified a conserved enhancer located 3' of the DIO3 gene containing putative AP-1 and serum response elements, that further increases the serum responsiveness of the Dio3 promoter in a cell-specific manner PMID: 12943987
    27. TGF-beta stimulates transcription of the hDio3 gene via a Smad-dependent pathway. PMID: 16037131
    28. structure and function of the type 3 deiodinase gene [review] PMID: 16131329
    29. postnatal expression of Dio3 can be reactivated in normal tissues during critical illness and other pathologic conditions [review] PMID: 16131330
    30. Deiodinase D3 exists as homo- or heterodimer in living intact cells, a feature that is critical for their catalytic activities. PMID: 18356288
    31. Prx3 knockdown resulted in a 50% decrease in D3-mediated whole-cell deiodination. PMID: 19819956

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  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Iodothyronine deiodinase family
  • 組織特異性：
    Expressed in placenta and several fetal tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2885

    OMIM: 601038

    KEGG: hsa:1735

    STRING: 9606.ENSP00000427336

    UniGene: Hs.49322