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DPY19L2 Antibody

  • 中文名稱：
    DPY19L2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA757514LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA757514LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DPY19L2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DPY19L2
  • 別名：
    DPY19L2 antibody; UNQ3127/PRO10284 antibody; Probable C-mannosyltransferase DPY19L2 antibody; EC 2.4.1.- antibody; Dpy-19-like protein 2 antibody; Protein dpy-19 homolog 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DPY19L2 Antibody (CSB-PA757514LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DPY19L2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA757514LB01HU DPY19L2 Antibody, HRP conjugated ELISA
    FITC CSB-PA757514LC01HU DPY19L2 Antibody, FITC conjugated
    Biotin CSB-PA757514LD01HU DPY19L2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
  • 基因功能參考文獻(xiàn)：
    1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
    2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
    3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
    4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
    5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
    6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
    7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
    8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
    9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
    10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957

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  • 相關(guān)疾?。?/div>
    Spermatogenic failure 9 (SPGF9)
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dpy-19 family
  • 組織特異性：
    Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19414

    OMIM: 613893

    KEGG: hsa:283417

    STRING: 9606.ENSP00000315988

    UniGene: Hs.533644