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DPYSL5 Antibody

  • 中文名稱：
    DPYSL5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA996118
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA996118(DPYSL5 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DPYSL5
  • 別名：
    Collapsin response mediator protein 5 antibody; CRAM antibody; CRMP 3 associated molecule antibody; CRMP 5 antibody; CRMP3 associated molecule antibody; Dihydropyrimidinase like 5 antibody; Dihydropyrimidinase related protein 5 antibody; Dihydropyrimidinase-related protein 5 antibody; DPYL5_HUMAN antibody; DPYS L5 antibody; DPYSL 5 antibody; DPYSL5 antibody; DRP 5 antibody; DRP5 antibody; FLJ45383 antibody; Ulip 6 antibody; Ulip6 antibody; ULIP6 protein antibody; UNC33-like phosphoprotein 6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human DPYSL5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    WB 1:200-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May have a function in neuronal differentiation and/or axon growth.
  • 基因功能參考文獻(xiàn)：
    1. Study describes the relevance of DRP5 during osteosarcoma development. DRP5 was upregulated in osteosarcoma specimens and cell lines and shown to function via the downstream MMPs. Inhibition of DRP5 suppressed the growth of cancer cells in vitro and in vivo, and high expression levels of DRP5 were associated with poor prognosis in osteosarcoma patients. PMID: 28374915
    2. Our findings suggest that CRMP5 serves as a major mediator of Notch signaling and Akt activation by controlling the degradation of the Notch receptor, with implications for defining a biomarker signature in glioblastoma PMID: 26122847
    3. present study suggested that CRAM could be a clinical prognostic marker for patients with cervical cancer PMID: 24695578
    4. study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function. PMID: 24324268
    5. identified residues that are crucial for determining the preference for hetero-oligomer or homo-oligomer formation. In spite of being the CRMP family member most closely related to dihydropyrimidinase, CRMP-5 does not have amidohydrolase activity. PMID: 23373749
    6. New CRMP5 isoform present in the nucleus is associated with Glioma. PMID: 23298946
    7. CRMP-5-IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells. PMID: 12838519
    8. CRMP-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk. PMID: 18306241
    9. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of paraneoplastic optic neuropathy secondary to lung cancer marked by an extremely high titer of CRMP-5 antibody. PMID: 18347453
    10. findings point at CRMP5 as a novel marker for distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers. PMID: 18769332
    11. patients with CV2/CRMP5-Ab and thymoma developed myasthenic syndrome more frequently PMID: 18931014

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20637

    OMIM: 608383

    KEGG: hsa:56896

    STRING: 9606.ENSP00000288699

    UniGene: Hs.299315