EDAR Antibody
-
中文名稱:EDAR兔多克隆抗體
-
貨號(hào):CSB-PA007391GA01HU
-
規(guī)格:¥3,900
-
其他:
產(chǎn)品詳情
-
Uniprot No.:
-
基因名:EDAR
-
別名:Anhidrotic ectodysplasin receptor 1 antibody; DL antibody; Downless (mouse) homolog antibody; Downless homolog antibody; Downless mouse homolog of antibody; ECTD10A antibody; ECTD10B antibody; Ectodermal dysplasia receptor antibody; Ectodysplasin 1 anhidrotic receptor antibody; Ectodysplasin A receptor antibody; Ectodysplasin A1 isoform receptor antibody; Ectodysplasin-A receptor antibody; ED 1R antibody; ED 3 antibody; ED 5 antibody; ED1R antibody; ED3 antibody; ED5 antibody; EDA 1R antibody; EDA 3 antibody; EDA A1 receptor antibody; EDA A1R antibody; EDA-A1 receptor antibody; EDA1R antibody; EDA3 antibody; Edar antibody; EDAR_HUMAN antibody; HRM1 antibody; Tumor necrosis factor receptor superfamily member EDAR antibody
-
宿主:Rabbit
-
反應(yīng)種屬:Human,Mouse,Rat
-
免疫原:Human EDAR
-
免疫原種屬:Homo sapiens (Human)
-
抗體亞型:IgG
-
純化方式:Antigen Affinity purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA,WB,IHC
-
Protocols:
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
-
基因功能參考文獻(xiàn):
- 10 and five quantitative trait-associated mutations for oxygen saturation (SaO2) and blood platelet count, respectively, are identified at the Edar Receptor (EDAR) locus. rs10865026 and rs3749110 (associated with SaO2 and platelet count, respectively) are functional candidate targets. EDAR has undergone natural selection in recent human history and EDAR variants has an important role in Tibetan high-altitude adaptations. PMID: 28795375
- Results suggested that SNPs in EDAR could be a pathogenic factor for non-syndromic tooth agenesis. Furthermore, EDAR can be regarded as a marker gene for the risk of tooth agenesis. PMID: 28808699
- To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575). PMID: 27487801
- Partial least square path model confirms EDARV370A systematically affect these weakly related ectodermal-derived characteristics, suggesting the pleiotropic effect of EDARV370A mainly plays roles in early embryo development PMID: 26603699
- Four traits of ear pinna anatomic variation are associated with a functional variant in the EDAR gene, a key regulator of embryonic skin appendage development. PMID: 26105758
- we have identi fi ed a novel frameshift mutation in an Italian family with autosomal dominant hypohidrotic ectodermal dysplasia resulting in a mild clinical phenotype. PMID: 24641098
- Individuals with a c.1072C > T mutation in the EDAR-gene displayed more hair shaft deformations confirming the role of EDAR for human hair follicle development and postnatal hair follicle cycling. PMID: 26336973
- Confirmed that EDARV370A, a variant that first originated in East Asia about 30000 years ago, played an important role in incisor shoveling in East Asia. This suggests that incisor shoveling in modern East Asians appeared after the late Pleistocene. PMID: 24752358
- Individuals with a c.1072C > T mutation in the EDAR-gene displayed a typical pattern of congenitally missing teeth in the frontal area with functional consequences. PMID: 24884697
- Using whole-exome sequencing we describe a novel homozygous missense mutation in EDAR causing autosomal recessive HED associated with palmoplantar hyperkeratosis and the absence of breasts. PMID: 23210707
- Study generated a knockin mouse model and found that, as in humans, hair thickness is increased in EDAR370A mice; new biological targets affected by the mutation were identified, including mammary and eccrine glands. Building on these results EDAR370A was found to be associated with an increased number of active eccrine glands in the Han Chinese. PMID: 23415220
- This is the first report of a founder EDAR mutation and of a significantly high frequency of autosomal recessive HED. PMID: 22032522
- WNT10A and EDAR were each responsible for 16% of hypohidrotic/anhidrotic ectodermal dysplasia cases. PMID: 20979233
- screening of all the 12 exons and splice junctions of gene EDAR revealed a novel missense mutation (c.1163T>C; p.Ile388Thr) in family A and a novel insertion mutation (c.1014insA; p.V339SfsX6) in family B. PMID: 21771270
- Data show that 25 different mutations on EDA and EDAR genes were detected in HED patients. PMID: 20236127
- a novel compound heterozygous mutation [c.52-2A>G; c.212G>A (p.Cys71Tyr)]; significance of the EDAR signalling pathway in the ectodermal morphogenesis. PMID: 20033817
- DNA sequence analysis of EDAR gene in a Pakistani family, demonstrating autosomal recessive form of hypohidrotic ectodermal dysplasia, identified a novel homozygous mutation affecting splice donor site of exon 5 [IVS5+1G > or = C] of the gene PMID: 20199431
- isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
- EDAR mutations account for one-quarter of non-ED1-related hypohidrotic ectodermal dyspl PMID: 16435307
- novel deletion mutation in a Pakistani family with autosomal recessive hypohidrotic ectodermal dysplasia PMID: 17501952
- study reports the molecular analyses of four patients from India with hypohidrotic ectodermal dysplasia, three who harbour novel mutations, two in the EDA gene and one in the EDAR gene PMID: 17970812
- EDAR is a major genetic determinant of Asian hair thickness and the 1540C allele spread through Asian populations due to recent positive selection PMID: 18065779
- Patients with homozygous or compound heterozygous mutations in the EDAR gene have a more severe phenotype of hypohidrotic ectodermal dysplasia than those with a heterozygous missense, nonsense or frame-shift mutation PMID: 18231121
- Study shows that the derived EDAR370A common in East Asia has a more potent signaling output than the ancestral EDAR370 V; shows that elevation of Edar activity in transgenic mice converts their hair phenotype to the typical East Asian morphology. PMID: 18561327
- EDAR is the genetic determinant of hair thickness as well as a strong contributor to hair fiber thickness variation among Asian populations. PMID: 18704500
- results expand the allelic series for mutations underlying hypohidrotic ectodermal dysplasia PMID: 19438931
- Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. PMID: 19551394
- an EDAR variant is a genetic determinant of shovel-shaped incisors PMID: 19804850
顯示更多
收起更多
-
相關(guān)疾?。?/div>Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A); Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B)亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.組織特異性:Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.數(shù)據(jù)庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-