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  4. EFHD2 Antibody, FITC conjugated

EFHD2 Antibody, FITC conjugated

  • 中文名稱：
    EFHD2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA856907LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EFHD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EFHD2
  • 別名：
    EF hand domain containing protein 2 antibody; EF hand domain family; member D2 antibody; EF-hand domain-containing protein D2 antibody; EFHD 2 antibody; EFHD2 antibody; EFHD2_HUMAN antibody; RP3-467K16.3 antibody; Swiprosin 1 antibody; Swiprosin-1 antibody; SWS1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human EF-hand domain-containing protein D2 protein (2-240AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
  • 基因功能參考文獻(xiàn)：
    1. Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2. PMID: 27974828
    2. Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure. PMID: 28011271
    3. The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state. PMID: 24917152
    4. EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia. PMID: 25383639
    5. Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity. PMID: 23977092
    6. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183 PMID: 23959172
    7. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration. PMID: 23331044
    8. the human Shu complex (hSWS1.SWSAP1) has an evolutionarily conserved function in homologous recombination PMID: 21965664
    9. This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
    10. Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes. PMID: 15274114
    11. These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway. PMID: 19693767

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  • 亞細(xì)胞定位：
    Membrane raft.
  • 組織特異性：
    Found in lymphocytes; preferentially expressed in CD8+ cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 28670

    OMIM: 616450

    KEGG: hsa:79180

    STRING: 9606.ENSP00000365147

    UniGene: Hs.465374