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ELMO1 Antibody

  • 中文名稱：
    ELMO1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004637
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of NIH-3T3 cells using Elmo1 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CED 12 antibody; Ced 12 homolog 1 antibody; Ced 12 homolog antibody; CED-12 antibody; CED12 antibody; Ced12 homolog 1 antibody; Ced12 homolog antibody; ELMO 1 antibody; ELMO-1 antibody; Elmo1 antibody; ELMO1_HUMAN antibody; Engulfment and cell motility 1 antibody; Engulfment and cell motility protein 1 antibody; KIAA0281 antibody; MGC126406 antibody; Protein ced-12 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Elmo1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • 基因功能參考文獻(xiàn)：
    1. ELMO1 genetic variation is associated with with type 2 diabetes. PMID: 28752301
    2. This study revealed the association of the SNP rs1345365 of the ELMO1 gene in a Mexican population PMID: 29938964
    3. A significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians. PMID: 27699784
    4. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module. PMID: 26882976
    5. ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity. PMID: 25901943
    6. Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration. PMID: 26205662
    7. high ELMO1 expression is an independent negative prognostic factor in normal karyotype (NK) acute myeloid leukemia. PMID: 25360637
    8. For ELMO1 (+9170 G>A), the GG genotype frequency was higher in the diabetic versus control group, but there were no differences between diabetic patients with and without nephropathies. PMID: 24433479
    9. Thus, Elmo1 and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis. PMID: 25586182
    10. There is a low frequency rate of the ancestral genotype for the ELMO1 polymorphism rs1345365 in mestizos from the western and southeastern regions of Mexico. PMID: 25167351
    11. High ELMO1 expression is associated with serous ovarian cancer. PMID: 24819662
    12. the present study characterized a novel Nck-1-ELMO1 interaction and defined a new role for Nck-1 in regulating Rac1 activity. PMID: 24928514
    13. findings reveal a previously unknown, nonredundant role for Elmo1 in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes. PMID: 24821968
    14. genetic association study in population in China: Data suggest that 2 SNPs in ELMO1 (rs741301; rs10951509) are associated with diabetic nephropathy in Chinese subjects with type 2 diabetes. PMID: 22842811
    15. ELMO1 mutations are associated with esophageal adenocarcinoma. PMID: 23525077
    16. Analysis of SNP databases of Japanese patuients with diabetic nephropathy revealed ELMO1 as a gene related to the above-cited diabetic complication. PMID: 23156397
    17. findings suggest that clearance of apoptotic cells in living vertebrates is accomplished by the combined actions of apoptotic cell migration and elmo1-dependent macrophage engulfment PMID: 22503503
    18. Over-expression of NELL1 is associated with alveolar rhabdomyosarcoma. PMID: 22415709
    19. The C-terminal Pro-rich tail of ELMO1 winds around the Src-homology 3 domain of DOCK2 to form an intermolecular 5-helix bundle. The entire regions of both DOCK2 a& ELMO1 assemble to create a rigid structure required for the DOCK2 & ELMO1 binding. PMID: 22331897
    20. We sequenced 17.4 kb of ELMO1 and identified 19 variants. PMID: 20826100
    21. The protein-protein interaction between ELMO1 and COX-2 increased the cyclooxygenase activity of COX-2 and, correspondingly, fibronectin expression.(ELMO1 protein, human) PMID: 20732417
    22. findings demonstrate an in vivo role for ELMO1-dependent clearance in the testes, with implications for spermatogenesis PMID: 20958313
    23. Dock180 ELMO complex functions as an unconventional two-part exchange factor for Rac. PMID: 12134158
    24. the association of DOCK2 with ELMO1 is critical for DOCK2-mediated Rac activation, thereby suggesting that their association might be a therapeutic target for immunologic disorders caused by lymphocyte infiltration PMID: 12829596
    25. Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 plays a role in cell migration PMID: 14638695
    26. Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis PMID: 14737186
    27. while N-terminal SH3 of CrkII promotes assembly between CrkII and DOCK180, the C-terminal SH3 of CrkII regulates the stability and turnover of the DOCK180/ELMO complex PMID: 15700267
    28. ELMO binding to the SH3 domain of Dock180 disrupted the SH3:Docker interaction, facilitated Rac access to the Docker domain, and contributed to the GEF activity of the Dock180/ELMO complex. PMID: 15723800
    29. These results indicate that ELMO1 is a novel candidate gene that both confers susceptibility to diabetic nephropathy and plays an important role in the development and progression of this disease. PMID: 15793258
    30. Src family kinase mediated tyrosine phosphorylation of ELMO1 might represent an important regulatory mechanism that controls signaling through the ELMO1/Crk/Dock180 pathway. PMID: 15952790
    31. ARNO and ARF6 coordinate with the Dock180/Elmo complex to promote Rac activation at the leading edge of migrating cells. PMID: 16213822
    32. Using pulldown assays, we identified engulfment and cell motility (ELMO) protein as the IpgB1 binding partner. IpgB1 colocalized with ELMO and Dock180 in membrane ruffles induced by Shigella. PMID: 17173036
    33. Overexpression of ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor is associated with glioma cell invasion PMID: 17671188
    34. The DOCK180-ELMO1 interaction is mapped to the N-terminal 200 amino acids of DOCK180, and to the C-terminal 200 amino acids of ELMO1, comprising the ELMO1 PH domain. PMID: 18768751
    35. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in African Americans. PMID: 19183347
    36. Report of genetic associations in ELMO1 with diabetic nephropathy, further establishing its role in the susceptibility of this disease. PMID: 19651817

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
  • 組織特異性：
    Widely expressed, with a higher expression in the spleen and placenta.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16286

    OMIM: 606420

    KEGG: hsa:9844

    STRING: 9606.ENSP00000312185

    UniGene: Hs.434989