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  4. ERCC6L Antibody

ERCC6L Antibody

  • 中文名稱：
    ERCC6L兔多克隆抗體
  • 貨號：
    CSB-PA076186
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA076186(ERCC6L Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA076186(ERCC6L Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ERCC6L
  • 別名：
    ATP dependent helicase ERCC6 like antibody; ATP-dependent helicase ERCC6-like antibody; DNA excision repair protein ERCC 6 like antibody; DNA excision repair protein ERCC-6-like antibody; ERC6L_HUMAN antibody; ERCC 6L antibody; Ercc6l antibody; Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody; Excision repair protein ERCC6 like antibody; FLJ20105 antibody; MGC131695 antibody; PICH antibody; Plk1 interacting checkpoint helicase antibody; PLK1-interacting checkpoint helicase antibody; SNF2/RAD54 family protein antibody; Tumor antigen BJ HCC 15 antibody; Tumor antigen BJ-HCC-15 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human ERCC6L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer. PMID: 30066865
    2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669
    3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction. PMID: 28977671
    4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported. PMID: 27487930
    5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported. PMID: 27565185
    6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported. PMID: 27230136
    7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID: 26643143
    8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate. PMID: 25564610
    9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids. PMID: 23973328
    10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process. PMID: 22563370
    11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes. PMID: 21743438
    12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture PMID: 20130082
    13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein. PMID: 19904549
    14. These data identify PICH as a novel essential component of checkpoint signaling. PMID: 17218258
    15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections. PMID: 17956945
    16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms. PMID: 18418076
    17. Functional characterization of the mouse Ercc6l ortholog. PMID: 15917148

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  • 亞細(xì)胞定位：
    Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20794

    OMIM: 300687

    KEGG: hsa:54821

    STRING: 9606.ENSP00000334675

    UniGene: Hs.47558