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ESRP2 Antibody, Biotin conjugated

  • 中文名稱：
    ESRP2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA007833LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ESRP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ESRP2
  • 別名：
    Epithelial splicing regulatory protein 2 antibody; ESRP 2 antibody; ESRP2 antibody; ESRP2_HUMAN antibody; FLJ21918 antibody; FLJ22248 antibody; RBM35B antibody; RNA binding motif protein 35A antibody; RNA binding motif protein 35B antibody; RNA binding protein 35B antibody; RNA-binding motif protein 35B antibody; RNA-binding protein 35B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Epithelial splicing regulatory protein 2 protein (615-720AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
  • 基因功能參考文獻(xiàn)：
    1. In conclusion, our findings suggested that IFNG-AS1 may function as an oncogene in pituitary adenoma by interacting with ESRP2. PMID: 30322807
    2. Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes. PMID: 26531099
    3. functions of the ESRP2 in an epithelial posttranscriptional gene expression program. PMID: 22354987
    4. ESRP2 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease. PMID: 20711167
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    ESRP family
  • 組織特異性：
    Epithelial cell-specific.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26152

    OMIM: 612960

    KEGG: hsa:80004

    STRING: 9606.ENSP00000418748

    UniGene: Hs.436585