EZH1 Antibody
-
中文名稱:EZH1兔多克隆抗體
-
貨號:CSB-PA852913DA01HU
-
規(guī)格:¥440
-
促銷:
-
圖片:
-
其他:
產(chǎn)品詳情
-
產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) EZH1 Polyclonal antibody
-
Uniprot No.:
-
基因名:
-
別名:Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody
-
宿主:Rabbit
-
反應(yīng)種屬:Human
-
免疫原:Recombinant Human Histone-lysine N-methyltransferase EZH1 protein (160-280AA)
-
免疫原種屬:Homo sapiens (Human)
-
標記方式:Non-conjugated
本頁面中的產(chǎn)品,EZH1 Antibody (CSB-PA852913DA01HU),的標記方式是Non-conjugated。對于EZH1 Antibody,我們還提供其他標記。見下表:
-
克隆類型:Polyclonal
-
抗體亞型:IgG
-
純化方式:>95%, Protein G purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA, IHC
-
推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
-
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
-
功能:Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
-
基因功能參考文獻:
- identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID: 29342143
- pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID: 28701475
- Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID: 28939884
- Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID: 27630126
- a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
- EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
- The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID: 28346433
- These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID: 27311868
- The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID: 25578878
- EZH1 maintains repressive chromatin through different mechanisms. PMID: 19026781
顯示更多
收起更多
-
亞細胞定位:Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
-
蛋白家族:Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-