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FAM161A Antibody

  • 中文名稱(chēng)：
    FAM161A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA661553LA01HU
  • 規(guī)格：
    ￥440
  • 促銷(xiāo)：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: FAM161A antibody at 8µg/ml
      Lane 1: Human placenta tissue
      Lane 2: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 77, 65, 84 kDa
      Observed band size: 77 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA661553LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA661553LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) FAM161A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FAM161A
  • 別名：
    F161A_HUMAN antibody; Fam161a antibody; Family with sequence similarity 161; member A antibody; FLJ13305 antibody; Hypothetical protein LOC84140 antibody; MGC129982 antibody; MGC129983 antibody; OTTHUMP00000201353 antibody; Protein FAM161A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein FAM161A protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，F(xiàn)AM161A Antibody (CSB-PA661553LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FAM161A Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA661553LB01HU FAM161A Antibody, HRP conjugated ELISA
    FITC CSB-PA661553LC01HU FAM161A Antibody, FITC conjugated
    Biotin CSB-PA661553LD01HU FAM161A Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in ciliogenesis.
  • 基因功能參考文獻(xiàn)：
    1. novel homozygous frameshift mutations of RP28-linked RP gene FAM161A in Indian population. PMID: 26246154
    2. Exome analysis revealed a nonsense homozygous mutation in FAM161A segregating with retinal degeneration with severe vision loss and a range of disease onset and progression. PMID: 25007332
    3. We screened a panel of 120 probands with recessive Retinitis Pigmentosa, and two were found to harbour biallelic FAM161A variants. PMID: 26113502
    4. founder mutation in FAM161A p.(Arg437*) underlies approximately 2% of arRP cases in the Dutch and Belgian populations. PMID: 26574802
    5. FAM161A's activities are probably not limited to ciliary tasks but also extend to more general cellular functions, highlighting possible novel mechanisms for the molecular pathology of retinal disease. PMID: 25749990
    6. Our data indicate that mutations in FAM161A are responsible for 1% of recessive RP cases in North America, similar to the prevalence detected in Germany and unlike the data from Israel and the Palestinian territories. PMID: 24651477
    7. Yeast two-hybrid screening of a human retinal cDNA library revealed FAM161A as a binary interaction partner of POC1B. PMID: 25018096
    8. an RP28 (an autosomal recessive form of retinitis pigmentosa)-linked RP family in the Palestinian population caused by a novel nonsense mutation in FAM161A, was identified. PMID: 24520187
    9. FAM161A is a novel centrosomal-ciliary protein that likely is implicated in the regulation of microtubule-based cellular processes in the retina. PMID: 24664697
    10. FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies. PMID: 22940612
    11. FAM161A is a microtubule-associated ciliary protein presumably involved in microtubule stabilization to maintain the microtubule tracks and/or in transport processes along microtubules in photoreceptors and other retinal cell types. PMID: 22791751
    12. Null mutations in FAM161A are responsible for the RP28-associated autosomal-recessive retinitis pigmentosa. PMID: 20705278
    13. These data suggest a pivotal role for FAM161A in photoreceptors and reveal that FAM161A loss-of-function mutations are a major cause of autosomal-recessive Retinitis pigmentosa. PMID: 20705279

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  • 相關(guān)疾?。?/div>
    Retinitis pigmentosa 28 (RP28)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Note=Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium.
  • 蛋白家族：
    FAM161 family
  • 組織特異性：
    Isoform 1 and isoform 3 are widely expressed with highest levels in retina and testis, with isoform 1 being the most abundant in all tissues tested.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25808

    OMIM: 606068

    KEGG: hsa:84140

    UniGene: Hs.440466