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FERMT3 Antibody

  • 中文名稱：
    FERMT3兔多克隆抗體
  • 貨號：
    CSB-PA008595GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    FERMT3
  • 別名：
    Fermitin family homolog 3 antibody; Fermitin family member 3 antibody; FERMT3 antibody; Kind3 antibody; Kindlin 3 antibody; Kindlin-3 antibody; Kindlin3 antibody; MGC10966 antibody; MIG 2 antibody; MIG2 like protein antibody; MIG2-like protein antibody; MIG2B antibody; Unc 112 related protein 2 antibody; Unc-112-related protein 2 antibody; UNC112C antibody; URP2 antibody; URP2_HUMAN antibody; URP2SF antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FERMT3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).; Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
  • 基因功能參考文獻：
    1. FERMT3 regulates glioma cell activity through integrin-mediated Wnt/beta-catenin signaling. PMID: 28778805
    2. Expression of Kindlin2 is associated with tumor grade. PMID: 28677779
    3. this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect PMID: 26359933
    4. kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion PMID: 26994136
    5. Kindlin-3 regulates c-Myc protein expression in the human chronic myeloid leukemia cell line K562. PMID: 26677948
    6. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution. PMID: 27101375
    7. Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma. PMID: 26334393
    8. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall. PMID: 26188538
    9. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease. PMID: 26282877
    10. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption. PMID: 25854317
    11. Mig-2 significantly attenuates the antitumor action of cisplatin. PMID: 25152024
    12. The data uncover a novel and unexpected tumor suppressor role of Kindlin-3 which can influence integrins targeted therapies development. PMID: 25344860
    13. High Kindlin-2 expression promotes pancreatic ductal adenocarcinoma progression. PMID: 25724625
    14. These data identify a role of kindlin-3 phosphorylation in integrin b3 activation and provide a basis for functional differences between kindlin-3 and the two other kindlin paralogs. PMID: 25609252
    15. Kindlin 2 expression was significantly increased in luteinized granulosa cells from patients with polycystic ovary syndrome. PMID: 24336678
    16. kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signaling circuit controlling cell migration and proliferation PMID: 25237194
    17. Direct activation of RhoA with recombinant bacterial cytotoxic necrotizing factor y reverted the abnormal phenotype and barrier function of kindlin-2-deficient keratinocytes and skin equivalents. PMID: 24615351
    18. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. PMID: 24523237
    19. Kindlin-3 influences breast cancer progression by influencing the crosstalk between beta1 integrins and Twist to increase VEGF production, which enhances breast cancer cell invasion and tumor angiogenesis and metastasis PMID: 24469992
    20. While Kindlin-2 was highly expressed in control tissues, a drastic low expression of Kindlin-2 was found in the tumor tissues of serous epithelial ovarian cancer, especially in high-grade serous epithelial ovarian cancer. PMID: 24583125
    21. kindlin-3-mediated high-affinity LFA-1 controls both the early transient integrin-dependent adhesions in addition to the final stable adhesions made under flow conditions PMID: 24010654
    22. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment PMID: 23823319
    23. kindlin-3 is required for the integrin alphaMbeta2-Syk-Vav1 signaling axis that regulates Rac1 and Cdc42 activities. These findings reinforce a role for kindlin-3 in integrin outside-in signaling. PMID: 23437269
    24. the correct functioning of the kindlin 3 PH domain is central to the role that kindlin 3 performs in guiding lymphocyte adhesion and motility behavior, which in turn is required for a successful immune response. PMID: 23595985
    25. Agonist stimulation, talin-1, and kindlin-3 are crucial for alpha(IIb)beta(3) activation in a human megakaryoblastic cell line, CMK. PMID: 23022222
    26. cleavage of Kindlin-3 by calpain controls the dynamics of integrin-Kindlin-3 interaction and as a result, integrin-dependent adhesion and migration of hematopoietic cells. PMID: 23012377
    27. Multivalent LFA-1/ICAM-1 bonds serve as mechanosensors that direct PMN cytoskeletal activity by transmission of tensile force to a supramolecular complex that triggers Ca2+ influx at sites of adhesive contact. PMID: 23144497
    28. kindlin-3 lowers the threshold for NK cell activation. Loss of kindlin-3 has a pronounced effect on NK cell-mediated cytotoxicity triggered by single activating receptors. PMID: 22983444
    29. Kindlin-3 deficiency impairs integrin function, including activation of beta(1) integrin. Abnormalities in glycoprotein Ib-IX function in Kindlin-3-deficient platelets are secondary to integrin defects PMID: 22564402
    30. integrin alphaLbeta2 engagement by its ligand ICAM-1 promotes the association of kindlin-3 with RACK1 PMID: 22334666
    31. LAD-III syndrome is caused by mutations in FERMT3, encoding the kindlin-3 protein in all blood cells that is involved in the regulation of beta integrin conformation. (Review) PMID: 22134107
    32. TIIICBP and kindlin-3 could be the same protein and propose a key role for kindlin-3 in platelet activation by type III collagen. PMID: 21871525
    33. A new mutation in codon 476 of exon 12, CAG-->TAG was found in 2 siblings with Leukocyte adhesion deficiency-I variant syndrome. PMID: 22139635
    34. We investigated the role of talin-1, kindlin-3, and alpha-actinin-1 in the upregulation of alpha(4)beta(1) integrin affinity and consequent inflammatory leukocyte adhesive events PMID: 21911599
    35. investigation into roles of kindlin-3 in activated T-cells: facilitates multimerization of LFA-1/ICAM-1; increases stability of focal LFA-1 contacts (presumably at immunological synapses)and anchors to cytoskeleton; facilitates T-cell spreading PMID: 21536861
    36. in two brothers with LAD-III syndrome homozygous mutation 1717C>T causes integrin-dependent platelet dysfunction in siblings with leukocyte adhesion deficiency-III PMID: 20216991
    37. LAD-III patient mutations have highlighted functionally important regions of kindlin-3 that alter leukocyte integrin-dependent function in 2 distinct ways. PMID: 20357244
    38. integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell PMID: 20378539
    39. cellular functions and possible clinical relevance of kindlin-3 [REVIEW] PMID: 19854292
    40. Studies indicate that LAD I is due to the mutations in beta2-integrin essential for firm adhesion. PMID: 19647987
    41. expressed preferentially in B cells; MIG2B is in a highly conserved and defined gene family containing two plasma-membrane-binding ezrin/radixin/moesin domains and a pleckstrin homology domain PMID: 12886250
    42. our data show for the first time that URP2SF may act as a transcriptional repressor in NF-kappaB signaling pathway and regulate cell apoptotic pathway. PMID: 18280249
    43. the LAD-III phenotype could manifest a combined defect in both upstream and downstream integrin regulatory effectors CalDAG-GEFI and Kindlin-3 PMID: 18779414
    44. Mutations in FERMT3 is associated with Leukocyte adhesion deficiency syndrome. PMID: 19064721
    45. Kindlin-3 is essential to activate the beta1, beta2 and beta3 integrin classes, and loss of Kindlin-3 function is sufficient to cause a LAD-III-like phenotype in mice PMID: 19234461
    46. identify mutations in the KINDLIN3 (official symbol FERMT3) gene specifying the KINDLIN-3 protein as the cause of leukocyte adhesion deficiency-III in Maltese and Turkish subjects PMID: 19234463
    47. Kindlin-3 is more critical to LFA-1 than to VLA-4-adhesive functions in human lymphocytes. PMID: 19617577

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  • 相關疾?。?/div>
    Leukocyte adhesion deficiency 3 (LAD3)
  • 亞細胞定位：
    Cell projection, podosome.
  • 蛋白家族：
    Kindlin family
  • 組織特異性：
    Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23151

    OMIM: 607901

    KEGG: hsa:83706

    STRING: 9606.ENSP00000279227

    UniGene: Hs.180535