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FKBP14 Antibody

  • 中文名稱：
    FKBP14兔多克隆抗體
  • 貨號(hào)：
    CSB-PA865159LA01HU
  • 規(guī)格：
    ￥440
  • 促銷(xiāo)：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: FKBP14 antibody at 1µg/ml
      Lane 1: Mouse stomach tissue
      Lane 2: Mouse gonadal tissue
      Lane 3: U937 whole cell lysate
      Lane 4: PC-3 whole cell lysate
      Lane 5: 293T whole cell lysate
      Lane 6: THP-1 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25 kDa
      Observed band size: 25 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FKBP14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FKBP14
  • 別名：
    22 kDa FK506 binding protein antibody; 22 kDa FK506-binding protein antibody; 22 kDa FKBP antibody; FK506 binding protein 14 (22 kDa) antibody; FK506 binding protein 14 antibody; FK506-binding protein 14 antibody; FKB14_HUMAN antibody; FKBP 22 antibody; FKBP-14 antibody; FKBP-22 antibody; FKBP14 antibody; FKBP22 antibody; FLJ20731 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP14 antibody; PPIase antibody; PPIase FKBP14 antibody; Rotamase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP14 protein (20-211AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，F(xiàn)KBP14 Antibody (CSB-PA865159LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FKBP14 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA865159LB01HU FKBP14 Antibody, HRP conjugated ELISA
    FITC CSB-PA865159LC01HU FKBP14 Antibody, FITC conjugated
    Biotin CSB-PA865159LD01HU FKBP14 Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.
  • 基因功能參考文獻(xiàn)：
    1. FKBP14 may act as an oncogene through suppressing apoptosis and promoting motility in human cervical carcinogenesis. PMID: 28731139
    2. Genetic studies showed that the patient harboured a homozygous mutation (c.362dupC p.Glu122Argfs*7) in the FKBP14 gene, confirming kyphoscoliotic EDS related to this gene. PMID: 27905128
    3. FKBP14 may act as an oncogene in osteosarcoma via suppressing apoptosis and promoting invasion and adhesion in osteosarcoma carcinogenesis PMID: 27223089
    4. this report describes a potentially life-threatening vascular complication in early pediatric age and atlantoaxial instability, suggesting the need for FKBP14-related EDS patients of tailored follow-up that includes cardiovascular monitoring, that is, cerebral, thoracic and abdominal MRA, and cervical dynamic radiograph. PMID: 27149304
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. FKBP14 expression was elevated in ovarian cancer tissues when compared with matched normal tissues. Lentiviral shRNA mediated knockdown of FKBP14 and suppressed the growth of ovarian cancer cells via arresting the cell cycle in the G0/G1 phase and stimulating cell apoptosis. Moreover, cell apoptosis induced by FKBP14 RNAi was mediated by enhancing the ratio of Bax/Bcl-2. PMID: 27131312
    7. Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in the G0/G1 phase and undergo apoptosis. PMID: 27931282
    8. the occurrence of umbilical skin redundancy in association with two other syndromes: Morquio syndrome and FKBP14-related Ehlers-Danlos syndrome (EDS), is reported. PMID: 24773188
    9. FKBP22 catalyzes the folding of type III collagen and only interacts with type III type VI and type X collagen. PMID: 24821723
    10. A 1.9 A resolution crystal structure for human FKBP22 has been determined. The EF-hand motifs of two FKBP22 molecules form a dimeric complex with an elongated and predominantly hydrophobic cavity that can potentially be occupied by an aliphatic ligand. PMID: 24272907
    11. study demonstrated FKBP14 is localized in the endoplasmic reticulum (ER) and that deficiency of FKBP14 leads to enlarged ER cisterns in dermal fibroblasts in vivo. PMID: 22265013

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  • 相關(guān)疾病：
    Ehlers-Danlos syndrome, with progressive kyphoscoliosis, myopathy, and hearing loss (EDSKMH)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18625

    OMIM: 614505

    KEGG: hsa:55033

    STRING: 9606.ENSP00000222803

    UniGene: Hs.390838