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FMNL1 Antibody

  • 中文名稱：
    FMNL1兔多克隆抗體
  • 貨號：
    CSB-PA104902
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: CSB-PA104902(FMNL1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    FMNL1
  • 別名：
    8030453N10Rik antibody; AI553564 antibody; C17orf1 antibody; C17orf1B antibody; CLL associated antigen KW 13 antibody; CLL-associated antigen KW-13 antibody; FHOD4 antibody; FMNL antibody; FMNL_HUMAN antibody; Fmnl1 antibody; Fnrl antibody; Formin like 1 antibody; Formin like antibody; Formin related protein antibody; Formin-like protein 1 antibody; Frls antibody; KW 13 antibody; KW13 antibody; Leukocyte formin antibody; MGC133052 antibody; MGC1894 antibody; MGC21878 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human FMNL1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
  • 基因功能參考文獻：
    1. FMNL1 contributes to leukemogenesis and could act in part through Rac1 regulation. PMID: 23801653
    2. constitutively activated form of FMNL1 (FMNL1gamma) induces localization of AHNAK1 to the cell membrane. PMID: 23182705
    3. Results suggest that macrophage coiling phagocytosis is a complex process involving several actin nucleation/regulatory factors. They also point specifically to the formins mDia1 and FMNL1 as novel regulators of spirochete uptake by human immune cells. PMID: 23460512
    4. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics. PMID: 21148482
    5. Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues. PMID: 20617518
    6. Results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells. PMID: 19815554
    7. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies, cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. PMID: 14592423

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome.; [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
  • 蛋白家族：
    Formin homology family
  • 組織特異性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1212

    OMIM: 604656

    KEGG: hsa:752

    STRING: 9606.ENSP00000329219

    UniGene: Hs.100217