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FOXJ1 Antibody

  • 中文名稱：
    FOXJ1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA549340
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from LOVO cells, using FOXJ1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FOXJ1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FOXJ1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human FOXJ1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
  • 基因功能參考文獻(xiàn)：
    1. Downregulation and aberrant localization of FOXJ1 may be crucial characteristics of the allergic nasal mucosa. PMID: 29635245
    2. Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer. PMID: 29129693
    3. Findings demonstrate that increased FOXJ1 contributes to the progression of CRC, which might be associated with the promotion effect of b-catenin nuclear translocation. PMID: 28209947
    4. In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome PMID: 26690880
    5. Decreased FOXJ1 expression was correlated with clinic stage, lymph node metastasis, and distant metastasis, and lower FOXJ1 expression independently predicted shorter survival time in gastric carcinoma. PMID: 24809300
    6. Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length PMID: 25201258
    7. By stimulating ciliogenesis with the transcription factor FOXJ1, it may be possible to maintain close to normal cilia length despite the stress of cigarette smoking. PMID: 24828273
    8. Nanog-mediated cell migration and invasion involved its regulation of E-cadherin and FOXJ1. PMID: 22945654
    9. FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1. PMID: 23822649
    10. FOXJ1 was overexpressed in HCCs and associated with histological grade and poor prognosis. PMID: 22488567
    11. Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression. PMID: 23479743
    12. goblet cells formed in response to IL-13 treatment are in part or wholly derived from progenitors that express the ciliated cell marker, FOXJ1 PMID: 20539013
    13. Single nucleotide polymorphisms were identified in FOXJ1 and a significant association was found with allergic rhinitis. PMID: 16518568

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  • 相關(guān)疾病：
    Allergic rhinitis (ALRH)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    FOXJ1 family
  • 組織特異性：
    Testis, oviduct, lung and brain cortex.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3816

    OMIM: 602291

    KEGG: hsa:2302

    STRING: 9606.ENSP00000323880

    UniGene: Hs.651204