Phospho-mFLNc (S2237) Antibody
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:Filamin-C, FLN-C, ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, Flnc, Abpl, Fln2
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反應(yīng)種屬:Mus musculus (Mouse)
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免疫原:Synthesized peptide derived from Mouse FLNc around the phosphorylation site of S2237.
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免疫原種屬:Mus musculus (Mouse)
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標(biāo)記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Affinity-purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
問答及客戶評(píng)論
我想要以下兩種抗體:在S2237位點(diǎn)磷酸化的小鼠FLNc (mFLNc),在S2236位點(diǎn)磷酸化的人類FLNc (hFLNc),這些是相同磷酸化殘基的小鼠和人類同源物。
靶點(diǎn)詳情
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功能:Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
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基因功能參考文獻(xiàn):
- HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
- The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
- Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
- KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
- filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
- These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
- MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
- Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075
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亞細(xì)胞定位:Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
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蛋白家族:Filamin family
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數(shù)據(jù)庫鏈接:
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