GALNT12 Antibody
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中文名稱:GALNT12兔多克隆抗體
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貨號:CSB-PA814224LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) GALNT12 Polyclonal antibody
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Uniprot No.:
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基因名:GALNT12
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別名:Colorectal cancer susceptibility to 1 antibody; CRCS1 antibody; FLJ21212 antibody; GalNAc T12 antibody; GalNAc-T12 antibody; GalNAcT12 antibody; GALNT 12 antibody; Galnt12 antibody; GLT12_HUMAN antibody; Polypeptide GalNAc transferase 12 antibody; Polypeptide N acetylgalactosaminyltransferase 12 antibody; Polypeptide N-acetylgalactosaminyltransferase 12 antibody; pp GaNTase 12 antibody; pp-GaNTase 12 antibody; Protein UDP acetylgalactosaminyltransferase 12 antibody; Protein-UDP acetylgalactosaminyltransferase 12 antibody; UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12 antibody; UDP GalNAc polypeptide N acetylgalactosaminyltransferase antibody; UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,GALNT12 Antibody (CSB-PA814224LA01HU),的標(biāo)記方式是Non-conjugated。對于GALNT12 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
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基因功能參考文獻(xiàn):
- LOH analyses, glycosylation pattern tests and case-control studies, our results did not support the role of c.907G>A, p.(D303N) as a high-penetrance risk allele for polyposis CRC PMID: 29095867
- Results rule out GALNT12 as a major high familial colorectal cancer susceptibility gene. Additional studies are required to provide further evidence about its role as a moderate/low susceptibility gene in familial aggregation of cancer. PMID: 24115450
- we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes. PMID: 24038392
- Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. PMID: 22461326
- cloning and characterization PMID: 12135769
- The expression of pp-GalNAc-T12 seems to be a negative marker especially of metastatic gastric and colorectal cancer PMID: 15557789
- inactivating GALNT12 mutations were identified as acquired somatic mutations in a set of 30 microsatellite stable colon tumors. PMID: 19617566
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相關(guān)疾?。?/div>Colorectal cancer 1 (CRCS1)亞細(xì)胞定位:Golgi apparatus membrane; Single-pass type II membrane protein.蛋白家族:Glycosyltransferase 2 family, GalNAc-T subfamily組織特異性:Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral c數(shù)據(jù)庫鏈接:
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