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GGA1 Antibody

  • 中文名稱：
    GGA1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA890911LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA890911LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA890911LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GGA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GGA1
  • 別名：
    4930406E12Rik antibody; ADP ribosylation factor binding protein 1 antibody; ADP ribosylation factor binding protein GGA1 antibody; ADP-ribosylation factor-binding protein GGA1 antibody; ARF binding protein 1 antibody; ARF-binding protein 1 antibody; Gamma adaptin related protein 1 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 1 antibody; GGA 1 antibody; GGA1 antibody; GGA1 protein antibody; GGA1_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF antibody; Golgi associated gamma adaptin ear containing ARF binding protein 1 antibody; Golgi localized gamma ear containing ARF binding protein 1 antibody; Golgi-localized antibody; OTTHUMP00000028975 antibody; OTTHUMP00000042200 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ADP-ribosylation factor-binding protein GGA1 protein (1-89AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，GGA1 Antibody (CSB-PA890911LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于GGA1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA890911LB01HU GGA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA890911LC01HU GGA1 Antibody, FITC conjugated
    Biotin CSB-PA890911LD01HU GGA1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
  • 基因功能參考文獻(xiàn)：
    1. These findings show that the AD-like phenotype of NPC model cells can be partly reverted by promoting a non-amyloidogenic processing of APP through the upregulation of GGA1 supporting its preventive role against AD PMID: 24866237
    2. On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment PMID: 22621900
    3. X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence PMID: 11859376
    4. The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF. PMID: 12668765
    5. X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain PMID: 12679809
    6. Crystal structure of the human GGA1 GAT domain PMID: 12767220
    7. A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5. PMID: 14636058
    8. GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region PMID: 14973137
    9. Rabaptin-5, ubiquitin, and TSG101 bind to overlapping but distinct binding sites on the trihelical bundle subdomain of GGA-1 protein PMID: 15143060
    10. Our data indicate that GGA proteins are not only involved in the sorting at the TGN but also mediate the retrograde transport of cargo proteins from endosomes to the TGN. PMID: 15886016
    11. the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles PMID: 16407204
    12. GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. PMID: 17005855
    13. GGA1 alters the proteolytic processing of beta-amyloid precursor protein (APP) and the secretion of APPs and amyloid-beta, suggesting a role of GGA1 in Alzheimer's disease pathogenesis. PMID: 17151287
    14. the interaction between the hinge region and the GAE domain underlies the autoregulation of GGA function in clathrin-mediated trafficking through competing with the accessory proteins and the AP-1 complex PMID: 17506864

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  • 亞細(xì)胞定位：
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    GGA protein family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17842

    OMIM: 606004

    KEGG: hsa:26088

    STRING: 9606.ENSP00000341344

    UniGene: Hs.499158