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GIMAP5 Antibody

  • 中文名稱：
    GIMAP5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019759
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells and HT-29 cells, using GIMAP5 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using GIMAP5 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GIMAP5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GIMAP5
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human GIMAP5.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues.
  • 基因功能參考文獻(xiàn)：
    1. GIMAP5 loss-of-function mutation results in T cell deficiencies. PMID: 29382851
    2. These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC. PMID: 27667392
    3. gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] PMID: 25944983
    4. Data indicate that overexpression of GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) in HEK (human embryonic kidney)-293 cells resulted in increased Ca2+ accumulation within the mitochondria. PMID: 23098229
    5. Notch signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5. PMID: 20817506
    6. These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis PMID: 20190135
    7. A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033). PMID: 17220214
    8. Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells. PMID: 17369194
    9. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease. PMID: 17641683
    10. Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population. PMID: 19762377

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  • 亞細(xì)胞定位：
    Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
  • 組織特異性：
    Widely expressed with high levels in lymph node and spleen. High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes. Very low expression levels in B-lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18005

    OMIM: 608086

    KEGG: hsa:55340

    STRING: 9606.ENSP00000351473

    UniGene: Hs.647079