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GOT2 Antibody

  • 中文名稱:
    GOT2兔多克隆抗體
  • 貨號:
    CSB-PA147812
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA147812(GOT2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA147812(GOT2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: 293T cells, Hela cells, Human fetal liver tissue, mouse spleen tissue, Mouse heart tissue, human fetal brain tissue, hepatocellular carcinoma tissue, Primary antibody: CSB-PA147812(GOT2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    GOT2
  • 別名:
    AATM_HUMAN antibody; AL022787 antibody; Aspartate aminotransferase 2 antibody; Aspartate aminotransferase antibody; Aspartate aminotransferase; mitochondrial antibody; Aspartate transaminase 2 antibody; ASPATA antibody; EC 2.6.1.1 antibody; FABP 1 antibody; FABP pm antibody; FABP-1 antibody; FABPpm antibody; Fatty acid binding protein antibody; Fatty acid-binding protein antibody; FLJ40994 antibody; Glutamate oxaloacetate transaminase 2 antibody; Glutamate oxaloacetate transaminase 2; mitochondrial antibody; Glutamate oxaloacetate transaminase; mitochondrial antibody; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) antibody; Got 2 antibody; GOT2 antibody; KAT4 antibody; KATIV antibody; kynurenine aminotransferase 4 antibody; Kynurenine aminotransferase IV antibody; kynurenine--oxoglutarate transaminase 4 antibody; kynurenine--oxoglutarate transaminase IV antibody; mAspAT antibody; MGC102129 antibody; MGC115763 antibody; mitAAT antibody; mitochondrial antibody; Mitochondrial aspartate aminotransferase antibody; OTTMUSP00000017748 antibody; Plasma membrane fatty acid binding protein antibody; Plasma membrane-associated fatty acid-binding protein antibody; Transaminase A antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GOT2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:100-1:300
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
  • 基因功能參考文獻(xiàn):
    1. Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
    2. The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
    3. Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
    4. Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
    5. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
    6. High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
    7. The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
    8. Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674

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  • 亞細(xì)胞定位:
    Mitochondrion matrix. Cell membrane.
  • 蛋白家族:
    Class-I pyridoxal-phosphate-dependent aminotransferase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4433

    OMIM: 138150

    KEGG: hsa:2806

    STRING: 9606.ENSP00000245206

    UniGene: Hs.599470