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GRM3 Antibody

  • 中文名稱：
    GRM3兔多克隆抗體
  • 貨號：
    CSB-PA622790LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA622790LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GRM3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GLUR3 antibody; Glutamate metabotropic receptor 3 antibody; Glutamate receptor metabotropic 3 antibody; GPRC1C antibody; GRM3 antibody; GRM3_HUMAN antibody; Metabotropic glutamate receptor 3 antibody; MGlu3 antibody; mGluR3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Metabotropic glutamate receptor 3 protein (46-354AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，GRM3 Antibody (CSB-PA622790LA01HU)，的標(biāo)記方式是Non-conjugated。對于GRM3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA622790LB01HU GRM3 Antibody, HRP conjugated ELISA
    FITC CSB-PA622790LC01HU GRM3 Antibody, FITC conjugated
    Biotin CSB-PA622790LD01HU GRM3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能參考文獻(xiàn)：
    1. experiments indicate that mGlu3Delta4 may negatively modulate mGlu3, and thereby impact on the roles of GRM3/mGlu3 in schizophrenia and as a therapeutic target PMID: 28655286
    2. Our findings support the GWAS-implicated link between GRM3 genetic variation and schizophrenia risk as well as the notion that alleles conferring this risk may be population specific. PMID: 28786982
    3. Results demonstrate that GRM3 expression is significantly upregulated in human colonic adenocarcinomas and colon cancer cell lines. This upregulation is mediated at the post-transcriptional level where miR-487b directly targets GRM3 to suppress its translation. Also, the fact that TGFbeta increases GRM3 protein stability provide novel mechanisms of post-transcriptional regulation of GRM3 in colon cancer. PMID: 28114282
    4. Low GRM3 expression is associated with multiple myeloma and B-cell leukemia. PMID: 27431857
    5. Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients. PMID: 26187343
    6. Results show that GRM3 rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype PMID: 25914064
    7. Grm3 expression was decreased in B cells from patients with autoimmune diseases such as activated systemic lupus erythematosus and multiple sclerosis. PMID: 26071318
    8. Pharmacogenetic relationships were identified in patients with schizophrenia between GRM3 variants and symptom response to antipsychotics. PMID: 25096017
    9. PI4KA and GRM3 polymorphisms have potential to jointly modulate antipsychotic response PMID: 25209194
    10. The mGluR3 promoted the proliferation of human embryonic cortical NPCs and increased cyclin D1 expression by activating ERK1/2 and JNK2 signaling pathways. PMID: 25198581
    11. The data of this study suggest an association of the GRM3 rs6465084 polymorphism with changes in pursuit maintenance after antipsychotic treatment. PMID: 24682224
    12. This study provided that the evidence for an association between GRM3 genotype and schizophrenia and suggest a role for glutamate neurotransmission in the establishment and maintenance of myelinated fibers. PMID: 24680030
    13. results supplied the first evidence that the polymorphism of GRM3 gene associates with the morbidity of alcohol dependence in human beings. PMID: 24585043
    14. report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production PMID: 24291464
    15. Data indicate that metabotropic glutamate receptor subtype 3 (mGluR3) polymorphisms do not contribute to genetic susceptibility to schizophrenia and depression, but they confer an increased risk of heroin dependence (HD) in a Chinese population. PMID: 24498053
    16. The transcript of mGlu3 receptors should be measured in tumor specimens for a correct prediction of patients' survival in response to temozolomide treatment. PMID: 23175182
    17. Kozak sequence variant associated with bipolar disorder PMID: 23575746
    18. glutamate system dysfunction may play a role in the prefrontal functional abnormalities seen in alcoholism. certain GRM3 SNP genotypes may further lower NAA/Cr levels and executive function in addition to the effect of alcohol. PMID: 22909248
    19. Polymorphisms in the GRM3 gene may be associated with refractory global psychosis symptoms but not negative symptoms in persons with schizophrenia. PMID: 21344500
    20. analysis suggested that mGluR3 is the major mGlu receptor expressed by adult cortical astrocytes, whereas the expression of other mGluRs was low or absent PMID: 23307741
    21. These results suggest that variations in GRM3 genotype modulate the auditory cortical response to phoneme change in humans. PMID: 22022368
    22. Melanoma cells expressing mutant GRM3 had reduced cell growth and cellular migration after short hairpin RNA-mediated knockdown of GRM3 or treatment with a selective MEK inhibitor, AZD-6244, which is currently being used in phase 2 clinical trials PMID: 21946352
    23. This study suggested a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia. PMID: 20638435
    24. Findings strongly suggest that the genetic variation (rs17676277 and three haplotypes) in the metabotropic glutamate receptor 3is related to cognitive setshifting in healthy individuals independent of working memory. PMID: 20132315
    25. An association is found between one marker (rs6465084) in glutamate receptor gene GRM3 and Japanese patients with major depressive disorder. PMID: 19386277
    26. results define a microenvironment within the binding pocket that encompasses several positively charged amino acids that recognize the negatively charged phosphonate group of l-AP4 or the endogenous compound l-serine-O-phosphate. PMID: 11744707
    27. genetic variation in the metabotropic glutamate receptor 3 gene that might contribute to genetic predisposition to schizophrenia and/or bipolar affective disorder PMID: 11840505
    28. At least one susceptibility locus for schizophrenia is situated within or very close to the GRM3 region in Japanese patients. PMID: 12782962
    29. mGluR3 and mGluR5 can critically and differentially modulate the expression of glutamate transporters and may represent interesting pharmacological targets to regulate the extracellular levels of glutamate in pathological conditions. PMID: 12786977
    30. glial progenitor cells present in the adult human CNS express mGluR3 and mGluR5a PMID: 15158450
    31. definition of the essential requirements for ligand binding to the extracellular domain of mGluR3 and highlight parameters important for the optimization of receptor expression in mammalian cells PMID: 15178451
    32. Reduction of mGluR3 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus. PMID: 15246118
    33. Data point to a specific molecular pathway by which metabotropic glutamate receptor GRM3 alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia. PMID: 15310849
    34. MGluR3 modulate the release of IL-6 in the presence of IL-1beta, supporting the role of mGluR3 in the regulation of the inflammatory and immune response associated with gliosis. PMID: 15652990
    35. GRM3 polymorphism may be associated with negative symptom improvement in persons with schizophrenia treated with olanzapine. PMID: 15913960
    36. The existence of the GRM3Delta4 isoform is relevant in the light of the reported association of non-coding single nucleotide polymorphisms (SNPs) in GRM3 with schizophrenia. PMID: 16417579
    37. SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT. PMID: 17006672
    38. mGlu3 receptor levels are altered in schizophrenia PMID: 17531207
    39. extend putative brain dopaminergic and glutamatergic relationships indexed by catechol-O-methyltransferase and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia PMID: 17636131
    40. we genotyped rs274622 in the promoter region of GRM3. In the present study, none of these polymorphisms were associated with schizophrenia PMID: 17948896
    41. Single nucleotide polymorphisms are not assoiated with schziphrenia. PMID: 18075480
    42. The study of DNA sequence variants in the GRM3 gene did not provide further support for genetic association with schizophrenia or for correlation with cognitive deficits. PMID: 18197082
    43. An exon 3 single nucleotide polymorphism (SNP) in GRM3 predicts increased splicing of the fourth exon and may contribute to risk for schizophrenia by modulating GRM3 splicing. PMID: 18256595
    44. The results of the present study indicate that the rs6465084 functional polymorphism in GRM3 does not contribute to genetic susceptibility to schizophrenia. PMID: 18412850
    45. these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of schizophrenia--REVIEW PMID: 18541626
    46. Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia. PMID: 18614340
    47. These data suggest that Glutamate receptor metabotropic 3 glutamate metabotropic receptor is disrupted in the AH in schizophrenia and localize the defect to the CA1 and CA3 regions. PMID: 19403271
    48. present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia PMID: 19439994

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4595

    OMIM: 601115

    KEGG: hsa:2913

    STRING: 9606.ENSP00000355316

    UniGene: Hs.590575