GRM6 Antibody
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中文名稱:GRM6兔多克隆抗體
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貨號:CSB-PA180398
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規(guī)格:¥2024
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圖片:
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Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR6 antibody.
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Western blot analysis of extracts from mouse brain, using GluR6 antibody.
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Western blot analysis of extracts from HepG2 cells (Lane 2), using mGluR6 antiobdy. The lane on the left is treated with synthesized peptide.
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) GRM6 Polyclonal antibody
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Uniprot No.:
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基因名:
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宿主:Rabbit
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反應種屬:Human
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免疫原:Synthesized peptide derived from Human GluR6.
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免疫原種屬:Homo sapiens (Human)
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克隆類型:Polyclonal
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式:Liquid
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應用范圍:ELISA,WB,IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
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基因功能參考文獻:
- Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
- Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness. PMID: 26628857
- These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin. PMID: 23452348
- We found 5 different mutations in GRM6, in congenital stationary night blindness. PMID: 23714322
- The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina. PMID: 22959359
- The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB). PMID: 22735794
- The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction. PMID: 22008250
- A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
- Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6. PMID: 16249515
- The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface. PMID: 17405131
- A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype. PMID: 19666700
- Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases. PMID: 19862333
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相關(guān)疾?。?/div>Night blindness, congenital stationary, 1B (CSNB1B)亞細胞定位:Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.蛋白家族:G-protein coupled receptor 3 family組織特異性:Detected in melanocytes.數(shù)據(jù)庫鏈接:
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