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HAGH Antibody

  • 中文名稱：
    HAGH兔多克隆抗體
  • 貨號：
    CSB-PA11195A0Rb
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA11195A0Rb at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HAGH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HAGH
  • 別名：
    HAGH antibody; GLO2 antibody; HAGH1Hydroxyacylglutathione hydrolase antibody; mitochondrial antibody; EC 3.1.2.6 antibody; Glyoxalase II antibody; Glx II antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Hydroxyacylglutathione hydrolase, mitochondrial protein (50-308AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，HAGH Antibody (CSB-PA11195A0Rb)，的標記方式是Non-conjugated。對于HAGH Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA11195B0Rb HAGH Antibody, HRP conjugated ELISA
    FITC CSB-PA11195C0Rb HAGH Antibody, FITC conjugated
    Biotin CSB-PA11195D0Rb HAGH Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
  • 基因功能參考文獻：
    1. Down regulation of Glyoxalase II was observed in cases of diabetic retinopathy as compared to controls. PMID: 29950256
    2. The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed. (GLO1, GLO2) PMID: 29385039
    3. epidermal expression stronger in older skin donors PMID: 26914966
    4. Glo2, together with Glo1, represents a novel mechanism in prostate cancer progression as part of a pathway driven by PTEN/PI3K/AKT/mTOR signaling. PMID: 27696457
    5. This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation. PMID: 27935136
    6. This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels. PMID: 25645869
    7. No association between genetic variants of the HAGH gene and autism spectrum disorder was found. PMID: 24671236
    8. hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II PMID: 15117945
    9. Overexpression of glyoxalase II is associated with kidney tumor PMID: 16803681
    10. Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. PMID: 16831876
    11. In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA. PMID: 18344682
    12. Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme PMID: 19413286

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  • 亞細胞定位：
    [Isoform 1]: Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 組織特異性：
    Expressed in liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4805

    OMIM: 138760

    KEGG: hsa:3029

    STRING: 9606.ENSP00000380514

    UniGene: Hs.157394