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  4. HBG1 Antibody, Biotin conjugated

HBG1 Antibody, Biotin conjugated

  • 中文名稱：
    HBG1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA010155HD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HBG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    HBG1 antibody; PRO2979 antibody; Hemoglobin subunit gamma-1 antibody; Gamma-1-globin antibody; Hb F Agamma antibody; Hemoglobin gamma-1 chain antibody; Hemoglobin gamma-A chain antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Hemoglobin subunit gamma-1 protein (2-147AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that studying genotype frequency of the Xmn1 gammaG globin polymorphism (-158C>T ) in Siwa Oasis, Egypt can be considered as a starting point for further research targeting this community sector. PMID: 29932071
    2. A significant relationship between two variations (+25G/A and -499T/A) in Agamma gene promotor and fetal hemoglobin levels was observed. PMID: 29412791
    3. study describes the characterization of the rs368698783 (+25 G->A) polymorphism of the Agamma-globin gene associated in beta(0)39 thalassemia patients with high HbF in erythroid precursor cells PMID: 28851297
    4. Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1. PMID: 28659276
    5. A Ly1 antibody reactive (LYAR)-binding motif disruptive regulatory single-nucleotide polymorphisms rs368698783 (G/A) from LD block 5 in the proximal promoter of hemoglobin subunit gamma 1 (HBG1) was found to be a significant predictor for beta-thalassemia clinical severity. PMID: 28669403
    6. Study found a novel polymorphism of the A-gamma-globin gene in four families with b0-thalassemia and high levels of HbF expression. Additionally, evidence suggesting that the Ac-globin gene +25(G-A) polymorphism decreases the efficiency of the interaction between this sequence and specific DNA binding protein complexes. PMID: 26897028
    7. These data confirm the regulatory role of the HBG1: g.-225_-222 region that exerts its effect under conditions of erythropoietic stress characteristic for beta-thal patients. PMID: 26575252
    8. Data show that the ancestral allele C at rs2855126, located upstream of gamma-globin (HBG1) is associated with increased serum uric acid levels. PMID: 26686224
    9. analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter PMID: 25971621
    10. a successful induction of gamma-globin includes a reduction in BCL11A, KLF1 and TAL1 expression. PMID: 26053062
    11. This report we discusses the molecular characteristics and diagnostic criteria of a new (A)gamma chain variant that was detected during newborn screening and named Hb F-Sykesville MD [(A)gamma113(G15)Val --> Ile; HBG1: c.340G>A]. PMID: 25565447
    12. Results indicate that compound II induces the gamma globin gene in hydroxyurea (HU)-resistant primary adult erythroid cells and suggest potenetial therapy for sickle cell disease (SCD) and severe beta-thalassemias. PMID: 25986606
    13. Inactivation of HDAC1 or HDAC2 induces gamma-globin expression without altering cell cycle or proliferation. PMID: 25808664
    14. There is synergism between developmental stage-specific recruitments of the ATF2 protein complex and expression of gamma-globin during erythropoiesis. PMID: 24223142
    15. data are consistent with a model in which WDR5 binds the gamma-globin promoter in a PRMT5-dependent manner. PMID: 22689669
    16. the stimulation of GPCRs supports the postulated connection between cAMP/PKA and NO/cGMP pathways in activation of gamma-globin expression, via JUN and p38 MAPK signaling. PMID: 23425329
    17. Methylation sites 28, 122, 231 and 234 bp of gamma-globin gene promoter are found both in patients with beta-thalassemia major and healthy adults. PMID: 22739173
    18. NF-Y recruits the developmentally regulated, erythroid transcription activator GATA-2 and general repressor BCL11A to modulate transcription of the gamma-globin gene. PMID: 23071749
    19. Activation of the p38 MAPK pathway by sodium butyrate augments gamma-globin expression through a CREB1 response element (CRE) that is present in the upstream promoter region of Ggamma gene. PMID: 22469229
    20. Three different gene rearrangements in three unrelated patients with the same breakpoints in the gamma-globin gene can lead to different levels of Hb A2 depending on the remaining number of gamma-globin genes. PMID: 22273484
    21. results establish SATB2 as a novel gamma-globin gene regulator and provide a glimpse of the differential and cooperative roles of SATB family proteins in modulating clustered genes transcription PMID: 22825848
    22. Alternative NLI complexes mediate gamma-globin transcription or silencing through long-range locus control region interactions involving an intergenic site of noncoding RNA transcription and that ETO2 is critical to this process. PMID: 22010104
    23. Low-dose hydroxyurea combined with sodium butyrate can up-regulate gamma globin gene expression in human erythroid progenitor cells. PMID: 19861270
    24. Sodium butyrate increases the level of acetylated histone in gamma-globin gene promoter regions. PMID: 20584642
    25. Xmn I polymorphism associated with concomitant activation of Ggamma and Agamma globin gene transcription on a beta0-thalassemia chromosome. PMID: 21144779
    26. polymorphisms -396_-391 del HBG2, -369 SNP HBG2 and -271 SNP HBG1 correlated with HbF levels, hence, it suggests an important role of HBG2 and HBG1 gene polymorphisms on the HbF synthesis. PMID: 20602015
    27. role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression PMID: 20439494
    28. Disrupting the bindings of the Oct-1 transcriptional factors with the decoy oligonucleotide provides a novel approach for inducing expression of the gamma-globin genes. PMID: 19327156
    29. the A allele of -588, [+] allele of XmnI and HS-111 (-21 A) variation are useful genetic markers to differentiate between beta-thalassemia major and beta-thalassemia intermedia patients PMID: 19958188
    30. the gamma-globin -195 mutation is the unique cause of elevation of Hb F in Brazilian hereditary persistence of fetal hemoglobin PMID: 19958189
    31. Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene PMID: 11960008
    32. DRED binds with high affinity to DR1 sites in the human epsilon & gamma globin promoters, but the adult beta-globin promoter has no DR1 element. An HPFH mutation in a DR1 site causes elevated gamma-globin transcription & reduces TR2/TR4 binding in vitro. PMID: 12093744
    33. Apicidin activates the A gamma globin gene promoter. Activation of the Agamma-globin promoter by apicidin could be inhibited by p38 inhibitor SB203580 PMID: 12393499
    34. In transgenic mice treated with short-chain fatty acid derivatives once daily for 5 days, human gamma globin mRNA increased 2-fold, reticulocytes increased 2-fold. PMID: 12393583
    35. human gamma-globin gene expression is developmentally regulated by the CCAAT box PMID: 14645237
    36. Direct repeat element in the promoter region of the gamma-globin gene autonomously mediates definitive stage-specific gene silencing. PMID: 15831451
    37. Together, these results show that the cAMP pathway blocks gamma-globin gene expression in K562 cells by increasing c-Myb expression. PMID: 16631597
    38. A novel gamma-globin-inducing short-chain fatty acid derivative (SCFAD), RB7, which was identified through computational modeling, produced a 6-fold induction in a reporter assay. PMID: 16849648
    39. These results suggest that different PKC isoforms may exert ontogenetic-specific functions in erythropoiesis and that modulation of PKCalpha might affect the activity of (A)gamma-promoter-driven reporters. PMID: 17212360
    40. data provide important clues for identifying and validating trans-activators that activate the gamma-globin gene in fetuses, and trans-acting factors involved in silencing the gamma-globin gene in adults PMID: 17612629
    41. analysis of a model for dynamic post-transcriptional control of gamma-globin gene expression, through modulation of the stability of its encoding mRNA PMID: 17976188
    42. study reports 2 new forms of nondeletional hereditary persistence of fetal hemoglobin; the presence of a (G)gamma-196 C-->T in the first case and an (A)gamma-201 C-->T in the second was revealed PMID: 18096417
    43. during definitive erythropoiesis, gamma-globin gene expression is silenced, in part, by binding a protein complex containing GATA-1, FOG-1, and Mi2 at the -566/-567 GATA sites of the proximal gamma-globin promoters PMID: 18347053
    44. Very low HBA2 levels of HBA2 in compound heterozygotes result from functional inhibition of the HBD gene in cis to the HBG1 gene bearing the nd-HPFH mutation. Absence of the HBG1:g.-225-222AGCAdel variation correlated with lower HbF & higher HbA2 levels. PMID: 18615450
    45. Observations from these two unique cases provide solid evidence that the Alphagamma - 158 C > T mutation plays an important role in Agamma-globin gene transcription. PMID: 18718799
    46. EKLF and the co-activator BRG1 are co-opted by short-chain fatty acid derivatives to activate the gamma globin genes PMID: 19220418
    47. The data suggest that miR-210 might be involved in increased expression of gamma-globin genes in differentiating erythroid cells. PMID: 19712585

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  • 蛋白家族：
    Globin family
  • 組織特異性：
    Red blood cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4831

    OMIM: 142200

    KEGG: hsa:3047

    UniGene: Hs.702189