HOME3_HUMAN antibody; HOMER 3 antibody; Homer 3D protein antibody; Homer homolog 3 (Drosophila) antibody; Homer neuronal immediate early gene 3 antibody; Homer protein homolog 3 antibody; Homer-3 antibody; Homer3 antibody; VESL3 antibody
宿主:
Rabbit
反應種屬:
Human,Mouse,Rat
免疫原:
Human HOMER3
免疫原種屬:
Homo sapiens (Human)
抗體亞型:
IgG
純化方式:
Antigen Affinity purified
濃度:
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
基因功能參考文獻:
Homer3 acts as a scaffold that spatially organizes actin assembly to support neutrophil polarity and motility downstream of GPCR activation. PMID: 25739453
Interaction of the protein with amyloid precursor protein is regulated by calcium homeostasis. PMID: 24792907
Loss of Homer3 is associated with acute myeloid leukemia. PMID: 23725168
Homer3 specifically associates with a novel ubiquitin-like domain in the I kappa B kinase (IKK) beta subunit of the IKK complex. PMID: 20693425
Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta. PMID: 14645007
Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells PMID: 16979624
study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin PMID: 18218901