HSD17B4 Antibody
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中文名稱:HSD17B4兔多克隆抗體
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貨號:CSB-PA005622
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:HSD17B4
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別名:12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase antibody; 17 beta HSD 4 antibody; 17 beta HSD IV antibody; 17 beta hydroxysteroid dehydrogenase 4 antibody; 17-beta-HSD 4 antibody; 17-beta-hydroxysteroid dehydrogenase 4 antibody; 17beta estradiol dehydrogenase type IV antibody; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody; 3-alpha antibody; 7-alpha antibody; Beta hydroxyacyl dehydrogenase antibody; Beta keto reductase antibody; D 3 hydroxyacyl CoA dehydratase antibody; D bifunctional protein antibody; D bifunctional protein peroxisomal antibody; D-3-hydroxyacyl CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein antibody; D-bifunctional protein antibody; D-bifunctional protein, peroxisomal antibody; DBP antibody; DBP, peroxisomal antibody; DHB4_HUMAN antibody; EDH17B4 antibody; Enoyl-CoA hydratase 2 antibody; Hsd17b4 antibody; Hydroxysteroid (17-beta) Dehydrogenase 4 antibody; MFE 2 antibody; MFE-2 antibody; MPF-2 antibody; Multifunctional protein 2 antibody; Peroxisomal multifunctional enzyme type 2 antibody; Peroxisomal multifunctional protein 2 antibody; PRLTS1 antibody; SDR8C1 antibody; Short chain dehydrogenase/reductase family 8C member 1 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from the N-terminal region of Human 17β-HSD4.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity.
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基因功能參考文獻(xiàn):
- This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation. PMID: 28296597
- we identified that methylation of the promoter CpG island of HSD17B4 was associated with the pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy with a specificity of 79% PMID: 28186977
- Our findings supported that HSD17B4 was one of the genes contributing to Perrault syndrome in this consanguineous Chinese Han family. PMID: 28830375
- ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
- Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC) cells and activated NF-kappaB co-localized with the NF-kappaB-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC progression. PMID: 25448063
- Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III. PMID: 23308274
- Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. PMID: 23181892
- Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP-2L (sterol carrier protein 2-like) domain in human and C. elegans proteins. PMID: 23313254
- Epistasis between the HSD17B4 and thyroglobulin polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF PMID: 22265031
- The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established. PMID: 20949532
- MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center PMID: 20566640
- Perrault syndrome and DBP deficiency overlap clinically and Perrault syndrome is genetically heterogeneous. PMID: 20673864
- rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma. PMID: 19776291
- crystal structure of 2-enoyl-CoA hydratase 2 PMID: 15644212
- Deficiency of this enzyme in man causes a severe developmental syndrome with abnormalities in several organs but in particular in the brain, leading to death within the first year of life. PMID: 16766224
- HSD17B4 is not only associated with the presence of prostate cancer, but is also a significant independent predictor of poor patient outcome. PMID: 19100308
- HSD17B4 mRNA is expressed in human skin, at similar levels in men and women. HSD17B4 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456
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相關(guān)疾?。?/div>D-bifunctional protein deficiency (DBPD); Perrault syndrome 1 (PRLTS1)亞細(xì)胞定位:Peroxisome.蛋白家族:Short-chain dehydrogenases/reductases (SDR) family組織特異性:Present in many tissues with highest concentrations in liver, heart, prostate and testis.數(shù)據(jù)庫鏈接:
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