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HSF2 Antibody, HRP conjugated

  • 中文名稱(chēng)：
    HSF2兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA010792LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) HSF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HSF2
  • 別名：
    Heat shock factor protein 2 antibody; Heat shock transcription factor 2 antibody; HSF 2 antibody; HSF2 antibody; HSF2_HUMAN antibody; HSTF 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Heat shock factor protein 2 protein (79-173AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
  • 基因功能參考文獻(xiàn)：
    1. Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells. PMID: 29799832
    2. HSF2 is a direct target of miR202 with a binding site on 3'-UTR of HSF2 mRNA in esophageal squamous cell carcinoma cells. PMID: 28277193
    3. This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies. PMID: 26119944
    4. Presented are the crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA. PMID: 26727490
    5. the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop. PMID: 26260034
    6. HSF2 can induce histone activation.Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
    7. HSF2 appears to be a potential novel molecular marker for ulcerative colitis PMID: 24533153
    8. the condensed chromatin of HSF2-deficient cells is accessible for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression. PMID: 25202032
    9. These results support a role for HSF2 in the pathogenesis of IA and further implicate this transcription factor as a potential therapeutic target. PMID: 23064888
    10. our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. PMID: 21792930
    11. Data show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2. PMID: 19768582
    12. characterization of the hsf2 gene and its 5'-flanking region PMID: 11795475
    13. HSF2 influences to the formation of nuclear stress granules PMID: 12865437
    14. HSF1 has a role in transcriptional regulation of the human RANK ligand gene PMID: 14699143
    15. results show hsp70i bookmarking is mediated by HSF2 which binds this promoter in mitotic cells, recruits protein phosphatase 2A & interacts with the CAP-G subunit of condensin to promote dephosphorylation & inactivation of condensin complexes PMID: 15662014
    16. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198
    17. During mitosis, HSF2 is bound to the HSE promoter elements of other heat shock genes, including hsp90 and hsp27, and the proto-oncogene c-fos. The presence of HSF2 is important for expression of these genes. PMID: 17915561
    18. MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
    19. These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. PMID: 18570919
    20. NMR study of the SUMOylated DNA binding domain of HSF2 indicates that the SUMO moiety is flexible with respect to the DNA binding domain and has neither a noncovalent interface with nor a structural effect on the domain PMID: 19017645
    21. HSF1-HSF2 heterotrimerization regulates stress-induced transcription PMID: 19129477

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
  • 蛋白家族：
    HSF family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 5225

    OMIM: 140581

    KEGG: hsa:3298

    STRING: 9606.ENSP00000357440

    UniGene: Hs.158195