HSPA4 Antibody

1. The dimerization of GRPEL2 may activate the folding machinery responsible for protein import into mitochondrial matrix or enhance the chaperone activity of mitochondrial HSP70, thus protecting mitochondrial proteostasis in oxidative stress. PMID: 30098457
2. ARD1-mediated Hsp70 acetylation is a regulatory mechanism that temporally balances protein refolding/degradation in response to stress PMID: 27708256
3. this study provided a mechanistic understanding of the dynamic nature of the polypeptide-binding pocket in the Hsp70 chaperone cycle. PMID: 29084938
4. Hsp70 protected human trabecular meshwork cells injury induced by UVB through Smad pathway; Hsp70 promoted cell proliferation and suppressed apoptosis. PMID: 29442021
5. Hsc70 and DNAJC14 are required for the unconventional trafficking of H723R-pendrin. PMID: 27109633
6. Laryngopharyngeal reflux may play a role in the development of chronic rhinosinusitis (CRS) through pepsin A reflux, and increased HSP70 expression may be associated with the pathogenic mechanism of mucosal injury in CRS. PMID: 28784015
7. Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis. PMID: 27941812
8. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes PMID: 28497897
9. we sought to investigate mechanisms mediated by Hsp70 acetylation in relation to apoptotic and autophagic programmed cell death. Upon stress-induced apoptosis, Hsp70 acetylation inhibits apoptotic cell death, mediated by Hsp70 association with apoptotic protease-activating factor (Apaf)-1 and apoptosis-inducing factor (AIF), key modulators of caspase-dependent and -independent apoptotic pathways, respectively PMID: 28627586
10. This review article documents reduced levels of mature miR-23a in various tumors, primarily due to epigenetic silencing or alterations in biogenesis pathways. Moreover, inhibition of miR-23a in stressed cells represent a general mechanism for inducing apoptosis and these microRNAs are showed to be regulated by molecular chaperon HSP70 PMID: 28453394
11. High Hsp70 and Hsp90 expression was associated with worse overall survival and disease-free survival [review and meta-analysis] PMID: 29491085
12. The level of Hsp70 was higher in the allergic rhinitis (AR) group compared with the non-AR group. Furthermore, treatment of HNE cells with Th2 cytokines induced secretion of Hsp70 into the extracellular area, and did not influence the production of Hsp70. These results suggest that Hsp70 may play a major role in the pathogenesis of AR. PMID: 28054753
13. The article results indicate that the heat-shock protein HSP70-2 (+1538 A/G) and HSP70-hom (+2437 C/T) SNPs are highly associated with renal complications in Type 2 Diabetes Mellitus among the South Indian population. PMID: 28246355
14. HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants. PMID: 28842558
15. verified the interaction of cellular chaperon HSP70 with Porcine reproductive and respiratory syndrome virus NSP12, and demonstrated that NSP12 could recruit HSP70 to maintain its own stability and benefit for the virus replication PMID: 27327135
16. Modulatory action of extracellular HSP70 on A549 inflammatory response through RAGE was able to evoke important expression changes in monocyte, showing its relevance in influencing the interaction between cancer and immune system cell. PMID: 28848092
17. Here the authors show that in budding yeast, Hsf1 basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 activity. PMID: 27831465
18. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value. PMID: 26886023
19. targeting the Hsp70 induction in Hsp90 inhibitor-treated cancer cells and tumor vasculature cells may beneficially enhance the radiosensitizing effect PMID: 28291803
20. The interaction of Fas receptor with FasL leads to an activation of the Tag7-Hsp70 complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex PMID: 27868339
21. Triptolide downregulates Sp1 and HSP70 mRNA in gastric cancer cell lines. PMID: 28192510
22. HSP70-TRIM32 complex is biochemically distinct from the previously characterized 14-3-3-TRIM32 phospho-complex. PMID: 28052117
23. There is overwhelming evidence that molecular chaperones such as Hsp27, Hsp70 and Hsp90 are expressed at elevated levels in a wide range of cancers by stabilizing the mutated neoplasm proteins. (Review) PMID: 26874923
24. HSP70 is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. PMID: 27137183
25. we demonstrated that upregulation of heat shock protein 70 (HSP70) was involved in both the promoted migration and the inhibited apoptosis of HepG2 cells in response to TNFalpha. Collectively, these findings indicate that TNFalpha alters protein expression such as HSP70, which triggering specific molecular processes and signaling cascades that promote migration and inhibit apoptosis of HepG2 cells. PMID: 28367089
26. The authors show here that both Escherichia coli ClpB and Saccharomyces cerevisiae Hsp104 cooperation with their cognate Hsp70 is crucial for efficient protein disaggregation and, in contrast to earlier claims, cannot be circumvented by activating M-domain mutations. PMID: 27616763
27. Each of HSPA4 and MED13 mutations were detected in GC. PMID: 27129500
28. Results identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. PMID: 26923191
29. the administration of exogenous HSP70 and the application of mild heat stress may produce a certain "rejuvenating" effect on mesenchymal stem cells. PMID: 27091568
30. the levels of serum HSP70 in patients with minor, moderate, and severe injuries were significantly higher than in healthy patients at each time point post-injury (P < 0.01), and levels of serum HSP70 in the severe injury group were significantly higher than in the minor injury group at 1-6 h after trauma (P = 0.047). PMID: 27137634
31. mammalian Hsp70 displayed a high specificity for negatively charged phospholipids, such as phosphatidyl serine, whereas DnaK interacted with all lipids tested regardless of the charge. PMID: 27075190
32. single nucleotide polymorphisms of tumour necrosis factors and HSP genes may have a role in nasopharyngeal carcinoma in North East India PMID: 26198046
33. The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFalpha secretion, and mRNA expression by human neuroblastoma SK-N-SH cells; exogenous HSP70 protects cells from the action of LPS, protection mechanism includes a reduction in the production of ROS and TNFalpha and a decrease in the expression of TLR4 and and IL-1beta mRNA PMID: 27599502
34. the HSP70-2 +1267 GG genotype and G alleles may increase the risk of GD in the Chinese population. PMID: 26782485
35. his review focuses on the regulation, function, and relevance of the molecular Hsp70 chaperone machinery to disease and its potential as a therapeutic target. PMID: 26865365
36. CAIII and Hsp70 expressions were higher in LPRD patients that in non-LPRD patients, suggesting the possibility as one of biomomarker in LPRD diagnosis. PMID: 26847302
37. MS5 induced hydrogen peroxide-mediated c-Jun-dependent Glo1 up-regulation which resulted in a decrease in the Argpyrimidine-modified Hsp70 protein level which triggered EMT in a novel mechanism involving miR-21 and SMAD signalling PMID: 26784015
38. Data suggest that dual heat shock proteins HSP90 and HSP70 inhibition can simultaneously disrupt the key signaling pathways in muscle invasive bladder cancer (MIBC). PMID: 26556859
39. quercetin-induced inhibition is involved in growth inhibition and sensitization to chemotherapy in lung cancer cells PMID: 26050647
40. Hsp70 overexpression likely plays an important role in the excessive collagen production by keloid fibroblasts. RNA interference has therapeutic potential for the treatment of keloids. PMID: 26446645
41. heat stress(HS) and aspirin + HS does not act as a co-inducer of HSP70 in HepG2 cells, but promotes Bcl-2 protein expression during prolonged treatment PMID: 25857363
42. AIF bears a HSP-70 binding domain allowing association with HSP-70. PMID: 26165468
43. HSP70 suppression elevates FOXM1 expression, and simultaneous inhibition of FOXM1 and HSP70 increases the sensitivity of human cancer cells to anticancer drug-induced apoptosis. PMID: 26559972
44. Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
45. Both intrinsic affinity and post-translational modifications tune the interactions between the Hsp70 and Hsp90 proteins and the tetratricopeptide repeat (TPR) domain-containing cochaperones. PMID: 26565746
46. Here we describe the small molecule, apoptozole (Az), which inhibits the ATPase activity of HSP70 by binding to its ATPase domain PMID: 25772468
47. As a chaperone of heat shock protein 70 (HSP70), HBP21 could inhibit interaction between HSP70 and Bax, increased Bax protein translocation from cytoplasm to mitochondria. PMID: 26246424
48. This study demonstrated that Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive. PMID: 26439956
49. BAG-3 expression correlated with increased HSP70 expression in a subset of systemic T cell lymphoma cases co-expressing the CD30 antigen. PMID: 24492285
50. These findings suggest that HSP70 genes are dependent of HLA-DR/DQ loci in governing susceptibility to PF. The multivariant regression analysis confirms this hypothesis. PMID: 25687737

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HGNC: 5237

OMIM: 601113

KEGG: hsa:3308

STRING: 9606.ENSP00000302961

UniGene: Hs.90093