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HSPB7 Antibody

  • 中文名稱：
    HSPB7兔多克隆抗體
  • 貨號(hào)：
    CSB-PA10979A0Rb
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA10979A0Rb at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HSPB7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HSPB7
  • 別名：
    Cardiovascular heat shock protein antibody; cvHsp antibody; DKFZp779D0968 antibody; FLJ32733 antibody; Heat shock 27kda protein family member 7 antibody; Heat shock protein beta 7 antibody; Heat shock protein beta-7 antibody; Hsp25 2 antibody; HspB7 antibody; HSPB7_HUMAN antibody; Hypothetical protein flj34956 antibody; RP11-5P18.6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Heat shock protein beta-7 protein (1-170AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，HSPB7 Antibody (CSB-PA10979A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于HSPB7 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA10979B0Rb HSPB7 Antibody, HRP conjugated ELISA
    FITC CSB-PA10979C0Rb HSPB7 Antibody, FITC conjugated
    Biotin CSB-PA10979D0Rb HSPB7 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Loss of Hspb7 in zebrafish or human cardiomyocytes stimulated autophagic pathways and expression of the sister gene encoding Hspb5. Inhibiting autophagy caused FilaminC aggregation in HSPB7 mutant human cardiomyocytes and developmental cardiomyopathy in hspb7 mutant zebrafish embryos. PMID: 29331499
    2. our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart. PMID: 28827800
    3. Patients with central sleep apnea and congestive heart failure had higher T allele frequencies in the HSPB7 gene. PMID: 27441470
    4. HSPB7 loci is associated in the pathophysiologuy of ischemic heart failure. PMID: 25889438
    5. Results imply that HSBP7 is likely to be a tumor suppressor gene regulated by p53 and its downregulation by hypermethylation may play a critical role in renal carcinogenesis. PMID: 24585183
    6. HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain. PMID: 22785082
    7. Data show a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM. PMID: 20975947
    8. The rs1738943 shows that although this SNP is located within HSPB7, it resides in a block of high LD that spans HSPB7 and a nearby gene, CLCNKA, which encodes a voltage-sensitive chloride channel expressed mainly in the kidney. PMID: 20124441
    9. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. PMID: 20038796
    10. HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding. PMID: 19464326

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • 蛋白家族：
    Small heat shock protein (HSP20) family
  • 組織特異性：
    Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5249

    OMIM: 610692

    KEGG: hsa:27129

    STRING: 9606.ENSP00000310111

    UniGene: Hs.502612