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HTR2A Antibody

  • 中文名稱：
    HTR2A兔多克隆抗體
  • 貨號：
    CSB-PA009355
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HTR2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SR-2A.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.; (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
  • 基因功能參考文獻：
    1. Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis. PMID: 30446669
    2. Polymorphisms within the HTR2A gene are associated with asthenozoospermia through sperm count and motility. PMID: 29602729
    3. Studied the genetic associations of human serotonin receptor gene polymorphism 5-HT2A T102C and behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). The TT genotype was found to be significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD. PMID: 29349076
    4. In schizophrenia patients, presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone. PMID: 28692863
    5. The DRD4 and 5HTR2A genes are co-expressed in Peripheral Blood Mononuclear Cells during antipsychotic administration. Despite a correlation between the studied biogenic amine indicators and the psychopathological status of patients, reliable biomarkers of treatment response could not be determined. PMID: 29221470
    6. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded. PMID: 29162169
    7. Imbalance in 5-HT2A may cause significant disturbances that lead to an increased susceptibility to death for individuals who are over 60 years of age. PMID: 28488759
    8. C102T (rs6313) polymorphism of 5-HTR2A gene may be involved in the susceptibility to suicide, higher number of stressful life and loss events, but A1438G (rs6311) and C1354T (rs6314) polymorphisms of 5-HTR2A gene were not associated with suicide, higher number of stressful life and loss events. PMID: 29526601
    9. Female anorexia nervosa patients with 5-HT2A -1438AA genotype may be characterized by less severe eating-disordered psychopathological traits in the Chinese Han population. PMID: 28639321
    10. The polymorphisms in HTR2A and GRIN2B were significantly associated with increased risk of chronic obstructive pulmonary disease. PMID: 28900078
    11. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization PMID: 28899696
    12. This study further advances the understanding of genetic variation and behavioral inhibition. Specifically, findings replicated previous associations between variation in the HTR2A and ANKK1 genes and inhibitory control as measured by a stop signal task. PMID: 29251981
    13. In four monozygotic twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. PMID: 27179966
    14. Study assessed role of 5-HT2A receptor to neurophysiological and psychological effects of ayahuasca. Ayahuasca induced an intense inhibitory effect on alpha oscillations in parieto-occipito-temporal cortex that correlated with visual phenomena. 5-HT2A receptor antagonist ketanserin effectively inhibited neurophysiological modifications, reduced correlation between alpha and the visual effects and subjective experience. PMID: 27039035
    15. These findings suggest that 5-HT promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones PMID: 29145495
    16. Individuals homozygous for the high-expressing 5-HT2A (T) allele exhibit diminished resting vagal tone-an index of stress vulnerability-when experiencing chronically elevated levels of perceived stress. PMID: 27912162
    17. A genomic association of the serotonin 2A receptor (5-HT2A) single nucleotide polymorphism (SNP), rs6313 C>T, with SB, where the C allele carrier is associated with a 4.25-fold increased risk of Sleep bruxism. PMID: 27916472
    18. results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. PMID: 27479537
    19. Occupational stress and 5-HTR2A genotypes in workers are associated both independently and in combination with increased risk of poor sleep quality. we found that the C allele of the 5-HTR2A gene and occupational stress are risk factors for poor sleep quality PMID: 27318223
    20. antisaccade latencies were slower for HTR2A rs6313 C allele homozygotes than T allele carriers, with no effect of genotype on prosaccade latencies PMID: 27161551
    21. A and T alleles of SNP rs6311 associated with cigarette smoking PMID: 28103253
    22. There was no significant association between the 5-HT2A gene and schizophrenia or major depressive disorder PMID: 27756686
    23. These data provide evidence that occupational stress and 5-HTR2A gene polymorphism contributes to the incidence of mental health problems. PMID: 28394294
    24. Data provide evidence that work stressors, low social support, and 5-HTR2A gene polymorphism contributes to the risk of job strain. PMID: 27999378
    25. Genetic loss of the 5-HT2A receptor compromised the activity of chronic treatment with selective serotonin reuptake inhibitors, making this receptor a putative marker to predict antidepressant response. PMID: 26764241
    26. Report on the synthesis, microsomal stability, and 5-HT2A/5-HT2C receptor profile of novel analogues of 25B-NBOMe modified at the primary site of metabolism; important information about the structure-activity relationship of this compound class was obtained, especially the fact that the 5'-methoxy-substituent is not crucial for binding to and activation of the 5-HT2AR as previous investigations have suggested PMID: 27564969
    27. Relative 5-HTR2A mRNA expression was significantly higher in PBMCs of all MDD patients when compared with healthy controls. PMID: 28125323
    28. heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively. PMID: 28258217
    29. HTR2A minor variant of -1438 A/G (G-allele) predicts greater speed-dating success for men. PMID: 27193909
    30. rs6311 and rs6313 polymorphisms of 5-HT2AR are not associated with schizophrenia. PMID: 27598719
    31. The HTR2A gene has been implicated as a major candidate for the serotonin disturbance seen in autism. PMID: 26149086
    32. The HTR2A 102T/C and -1438A/G polymorphisms may not be associated with susceptibility to Tourette syndrome in the Chinese Han population. PMID: 25858583
    33. The current results also emphasize the importance of 5-HT2A/1A receptor subtypes and the Asp system in the control of social functioning, and as prospective targets in the treatment of sociocognitive impairments in psychiatric illnesses. PMID: 27091970
    34. Results of this investigation provide preliminary evidence that the combined analysis of CpG SNPs and methylation may be useful for investigating the genetic and epigenetic factors involved in suicidal behavior. Study did not find strong evidence for epigenetic changes in the serotonin 2A receptor associated with suicidal behavior. PMID: 26812280
    35. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. PMID: 26758213
    36. Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line PMID: 26768715
    37. increased gene expression in peripheral blood mononuclear cells of asthma patients PMID: 26234928
    38. human HTR2A gene spans ~66 kilobases and consists of 7, rather than 4 exons; Furthermore, the revised human HTR2A-AS1 gene spans ~474 kilobases and consists of 18, rather than 3 exons PMID: 26738766
    39. No significant association between candidate gene variants and criminal behavior was detected. PMID: 26041607
    40. OSAHS group had significantly higher AA genotype and A allele frequencies in the A1438G polymorphisms of the 5-HTR 2A gene, and had significantly higher frequencies of 10/10, 12/10 genotypes and the allele 10 of 5-HTT-VNTR. PMID: 23494654
    41. signal transduction pathways downstream of 5-HT6R are regulated by MAP1B, which might play a role in 5-HT6R-mediated signaling in the brain. PMID: 24614691
    42. The widely replicated 102C > T polymorphism in the HTR2A gene showed a statistically significant drug-gene interaction with serotonin uptake inhibitors use. PMID: 25649181
    43. This study showed that there were no differences in allele frequencies for the STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G polymorphisms. PMID: 25772786
    44. Results show plasticity and region specificity of serotonin 2A receptor expression regulation in human brain with age. PMID: 25041420
    45. Single marker association analyses between genotypes and aggression scores indicated a significant role of rs7322347 located in the HTR2A gene encoding serotonin receptor 2a both for males and females. PMID: 25658328
    46. The middle frontal gyrus and anterior cingulate cortex /inferior parietal lobule activations were sensitive to differences between the COMT genotypes and between the HTR2A genotypes, respectively. PMID: 25974269
    47. These results indicate that DRD2 and HTR2A genetic variants together modulate physiological prefrontal efficiency during working memory and also modulate the response to antipsychotics. PMID: 25563748
    48. This meta-analysis does not support the previously suggested association between HTR2A 102T/C and attempted suicide in the general population, but in patients with schizophrenia, the C/C genotype may increase the risk of attempted suicide. PMID: 26075944
    49. functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2 PMID: 25314362
    50. This study indicated an association between the SNPs (rs6311 and rs6313) of the serotonin receptor 5HT2A and schizophrenia PMID: 25758572

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Cell junction, synapse, presynapse.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Detected in brain cortex (at protein level). Detected in blood platelets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5293

    OMIM: 182135

    KEGG: hsa:3356

    STRING: 9606.ENSP00000367959

    UniGene: Hs.72630