HTR4 Antibody
-
中文名稱(chēng):HTR4兔多克隆抗體
-
貨號(hào):CSB-PA790181
-
規(guī)格:¥1100
-
圖片:
-
其他:
產(chǎn)品詳情
-
Uniprot No.:
-
基因名:
-
別名:HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4
-
宿主:Rabbit
-
反應(yīng)種屬:Human,Mouse,Rat
-
免疫原:Synthetic peptide of Human HTR4
-
免疫原種屬:Homo sapiens (Human)
-
標(biāo)記方式:Non-conjugated
-
抗體亞型:IgG
-
純化方式:Antigen affinity purification
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
-
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA,WB
-
推薦稀釋比:
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols:
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
-
基因功能參考文獻(xiàn):
- found that testosterone, but not estradiol, correlated negatively with global 5-HT4R levels suggesting that men with high levels of testosterone have higher cerebral serotonergic tonus. PMID: 28426945
- l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo. PMID: 28103616
- Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride PMID: 27438088
- Findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans PMID: 28413715
- Results of this study indicated that HTR4 signaling upregulated ERbeta expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer. PMID: 28195088
- Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder PMID: 25522384
- PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling. PMID: 25101859
- The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies. PMID: 25342126
- This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory. PMID: 25622143
- ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
- This is the first transgenic model to study human 5-HTreceptor in the atrium ex vivo or in vivo. PMID: 23307014
- Stimulation of central 5-HT4 receptors is potentially disease-modifying in a transgenic mouse model of Alzheimer's disease. PMID: 23474291
- Taken together, these data suggest a role for HTR4 in lung development, which may at least in part explain the genetic association with lung function. PMID: 23890215
- Our results suggest that HTR4 polymorphisms may not play a major role in the susceptibility for suicidal behavior in subjects with schizophrenia. PMID: 22842674
- These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis. PMID: 22903372
- Results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction. PMID: 22837378
- Our findings are consistent with a model wherein the 5-HTTLPR S allele is associated with relatively increased serotonin levels. PMID: 22584237
- These findings suggest that the 5-HT(4)R is critically involved in reward circuits that regulate people's food intake PMID: 22709820
- Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. PMID: 22226658
- The occurrence of heterogeneous post-translational modifications (PTMs) on transgenic proteins, as well as the complications that non-native PTMs can cause, highlight the characterization of both endogenous and heterologous protein targets. PMID: 22145929
- 5-HT4 receptor binding was a positively correlated to amyloid beta (A4) burden and negatively to MMSE score of the Alzheimer disease patients PMID: 21673407
- HTR4 polymorphism associated with COPD risk and lung function decline PMID: 21965014
- SNP and haplotypes of the HTR4 gene were associated with the asthma phenotype and genetic variation of HTR4 may affect susceptibility to the development of asthma. PMID: 21382128
- The relatively stable HT4 5- receptor binding with aging contrasts others in subtypes of receptors, which generally decrease with aging. PMID: 21364600
- This study demonistrated that 5-HT4 receptor is present in the human thalamus prenatally. PMID: 20538346
- No association was found in the family sample betweewn HTR4 and schizophrenia. PMID: 19892407
- Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease. PMID: 20010834
- Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. PMID: 11989623
- The polymorphisms associated with mood disorder were located within the region that encodes the divergent C-terminal tails of the 5-HT(4) receptor. PMID: 12399948
- report the activation of the extracellular signal-regulated kinases (ERKs) 1 and 2 (p44 and p42 MAP kinase) through the human serotonin receptors 5-HT(4(b)) and 5-HT(7(a)) PMID: 12446729
- results show an overexpression of the 5-HT4 receptor in cisapride-responsive ACTH-independent bilateral macronodular adrenal hyperplasia PMID: 12519861
- A highly significant association between schizophrenia and haplotype A-T (OR = 0.13 [0.03-0.58]) was detected. PMID: 12898568
- Our results suggest a complex regulation of the h5-HT4 receptor gene expression involving distinct promoters and non-coding exons. PMID: 15575821
- secretion of the non-amyloidogenic form of amyloid precursor protein, sAPPalpha induced by the 5-HT4(e) receptor isoform was not due to a general boost of the constitutive secretory pathway but rather to its specific effect on alpha-secretase activity PMID: 15710402
- inhibition of Na+/H+ exchange activity by serotonin is mediated by 5-HT4 receptors in Caco-2 cells PMID: 15825078
- coexpression of h5-HT4R and beta2-adrenergic receptor (beta2AR) led to their heterodimerization PMID: 15896782
- the uncoupling and endocytosis of 5-HT4R require different GRK2 concentrations and involve distinct molecular events PMID: 15919661
- development of an adenovirus expression system to examine the properties of two human 5-HT4 receptor splice variants, h5-HT4(b) and h5-HT4(d), expressed in adult cardiomyocytes devoid of native 5-HT4 receptors PMID: 15950987
- These findings provide the first evidence of differential internalization between the two splice variants, 5-HT(4a) and 5-HT(4b) receptors. PMID: 16209130
- We show overexpression & different splicing of 5-HT4 receptor in aldosterone-producing adenoma tissues in comparison with normal adrenocortical tissue.Isoforms (a) & (b) were not expressed in any APA but were present in majority of normal adrenal cortex. PMID: 16322401
- These results suggest that the HTR4 gene may play a role in the genetic predisposition to ADHD. PMID: 16563621
- Data show that 5-HT(4) receptor stimulation in primary neurons produced a potent but transient activation of the ERK pathway that is dependent on Src tyrosine kinase but totally independent of beta-arrestin. PMID: 17377064
- We show that disulfide bridges between Cys112 and Cys145 located within transmembrane domain 3 and transmembrane domain 4, respectively, are of critical importance for 5-HT(4)R dimer formation. PMID: 17379184
- Our results indicate that h5-HT(4(b)) is the dominant cardiac isoform of human 5-HT(4) receptors and its expression is increased in CAF. PMID: 17418812
- Functional activiy of 5-HT4 receptors was studied in children with congenital heart disease. PMID: 17603679
- In this review, the pathways regulating either beta- or gamma-secretase may be differentially controlled by 5-HT4 receptor isoforms. PMID: 18322379
- In failing human ventricle, 5-HT(4) receptor-mediated positive inotropic response was regulated by PDEs in a manner similar to that in postinfarction rat hearts;5-HT, PDE3 and PDE4 may have pathophysiological functions in heart failure. PMID: 18846035
- 5-HT4 expression is lower in heart ventricle vs. atrium. Isoform expression in atrium and ventricle is similar. There is a parallel increase of cAMP and in the phosphorylation state of regulatory proteins following stimulation with 5-HT in the atrium. PMID: 19002436
- The human 5HT4 receptor, when placed under the influence of the mouse opsin promoter and an opsin rod outer segment (ROS) targeting sequence, localized to ROS of transgenic mouse retina. PMID: 19053287
- This paper presents an analysis of the SH3TC2 promoter after identifying a read-through transcript of the SH3TC2 and HTR4 loci. Available data suggests HTR4 is a separate locus with its own promoter, and not the product of a bi-cistronic transcript. PMID: 11716477
顯示更多
收起更多
-
亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein. Endosome.
-
蛋白家族:G-protein coupled receptor 1 family
-
組織特異性:Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
-
數(shù)據(jù)庫(kù)鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-