Hp Antibody
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中文名稱:Hp兔多克隆抗體
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貨號:CSB-PA17069A0Rb
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Rattus norvegicus (Rat) Hp Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:Hp antibody; Ba1-647 antibody; Haptoglobin antibody; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] antibody
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宿主:Rabbit
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反應種屬:Rat
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免疫原:Recombinant Rat Haptoglobin protein (19-346AA)
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免疫原種屬:Rattus norvegicus (Rat)
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標記方式:Non-conjugated
本頁面中的產(chǎn)品,Hp Antibody (CSB-PA17069A0Rb),的標記方式是Non-conjugated。對于Hp Antibody,我們還提供其他標記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應用范圍:ELISA, WB, IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
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基因功能參考文獻:
- This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID: 23172820
- Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID: 22254015
- activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID: 20155810
- Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID: 20016097
- Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID: 11865979
- Haptoglobin gene expression regulation PMID: 11865981
- Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID: 11991649
- upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID: 12368655
- Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID: 16172914
- Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID: 17616219
- that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID: 17910034
- lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID: 19521970
- Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID: 19545490
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亞細胞定位:Secreted.
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蛋白家族:Peptidase S1 family
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組織特異性:Expressed by the liver and secreted in plasma.
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數(shù)據(jù)庫鏈接:
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