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Hras Antibody, Biotin conjugated

  • 中文名稱：
    Hras兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA15539D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Rattus norvegicus (Rat) Hras Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Hras
  • 別名：
    Hras antibody; Hras1 antibody; GTPase HRas antibody; H-Ras-1 antibody; Transforming protein p21 antibody; c-H-ras antibody; p21ras) [Cleaved into: GTPase HRas antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Rat
  • 免疫原：
    Recombinant Rat GTPase HRas protein (2-186AA)
  • 免疫原種屬：
    Rattus norvegicus (Rat)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • 基因功能參考文獻(xiàn)：
    1. Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene. PMID: 27125250
    2. H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway. PMID: 28193718
    3. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. PMID: 26568031
    4. H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel PMID: 25774517
    5. Data indicate that numerous proteins that are up-regulated in H-ras(G12V) transgenic rat pancreatic ductal adenocarcinoma (PDAC) are also up-regulated in human PDAC; therefore, this rat model can be used for diagnostic biomarkers for this disease. PMID: 23648844
    6. Fe(2+)-generated O(2) mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in hepatic macrophages PMID: 22829592
    7. The proto-oncogenic H-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways. PMID: 20603646
    8. Data show that Myc repressed Ras-induced senescence, and that Cdk2 interacted with Myc at promoters, where it affected Myc-dependent regulation of genes, including those of proteins known to control senescence. PMID: 19966300
    9. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal access to the endocytic compartment and whether this access is necessary for downstream signaling. PMID: 12077341
    10. A positive regulatory role of Ras is observed in AMPA receptor-mediated synaptic transmission in hippocampal pyramidal neurons. PMID: 12824760
    11. Functional activation of H-Ras might be one of the signaling steps involved in glucose-induced capillary cell apoptosis. PMID: 14988264
    12. Silencing of individual genes by DNA methylation is controlled by HRAS oncogenic signalling pathways, yet the mechanisms responsible for initial target gene suppression are variable. PMID: 16568090
    13. H-ras suppresses integrin affinity via independent Raf and phospholipase C epsilon signaling pathways. PMID: 16895916
    14. analysis of tumor induction with expression plasmids for activated H-ras and c-myc PMID: 18218323
    15. Infection with M. arginini made rat and mouse embryo fibroblasts susceptible to transformation with oncogenic H-Ras PMID: 18408766
    16. induction of long-term potentiation triggered robust Ca2+-dependent Ras activation in single spines that decayed in approximately 5 minutes; Ras activity spread over approximately 10 micrometers of dendrite and invaded neighboring spines by diffusion PMID: 18556515
    17. trend of increased H-ras expression was observed in diabetic compared to normal rats during oncogenesis PMID: 19283661

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  • 亞細(xì)胞定位：
    Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數(shù)據(jù)庫鏈接：