IFNL1 Antibody
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中文名稱:IFNL1兔多克隆抗體
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貨號:CSB-PA13249A0Rb
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) IFNL1 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:IFNL1 antibody; IL29 antibody; ZCYTO21Interferon lambda-1 antibody; IFN-lambda-1 antibody; Cytokine Zcyto21 antibody; Interleukin-29 antibody; IL-29 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Interferon lambda-1 protein (21-200AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,IFNL1 Antibody (CSB-PA13249A0Rb),的標(biāo)記方式是Non-conjugated。對于IFNL1 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
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基因功能參考文獻(xiàn):
- SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
- In conclusion, IL-29 enhanced CXCL10 production in human oral epithelial cells via the p38 MAPK, STAT3, and NF-kappaB pathways, which might control Th1-cell accumulation in periodontal lesions and be involved in pathological processes in periodontal disease. PMID: 28753407
- The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection. PMID: 28720717
- The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses). PMID: 27544015
- Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation. PMID: 28678391
- IFN-lambda1 may play an important role in anti-respiratory syncytial virus infection. PMID: 28606236
- Ebola virus VP24, in addition of inhibiting IFN-induced antiviral responses, was found to efficiently inhibit type III IFN-lambda1 gene expression. PMID: 28595092
- STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site. PMID: 28165510
- IFN-lambda1 is likely to play a role in the pathogenesis of CSU. Blocking IFN-lambda1 production may help to reduce the accumulation of inflammatory cells in the involved CSU skin. PMID: 27445435
- IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA. PMID: 27433031
- IL-29 is a potential biomarker for disease activity in anti-cyclic citrullinated peptide-antibodies positive rheumatoid arthritis patients. PMID: 28154345
- this study shows that serum levels of IL-29 play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey PMID: 27617784
- serum levels of IL-32 and TNF-alpha may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer PMID: 26219901
- Serum levels of IL-29 and IFN-gamma are predictive of relapse outcomes after hepatitis C treatment. PMID: 26342113
- IL-29 selectively induces CXCR3A-binding chemokines (CXCL9, CXCL10, CXCL11) in skin cells. Murine IL-29 counterpart induces skin T-cell infiltration and inflammation in mice. PMID: 26612594
- activation of TLR7 upregulated the expression levels of IFN-lambda1 and MMP-9 were increased by ~3 fold, whereas other genes (p53, PTEN, TIMP-1) were upregulated by ~2 fold, and VEGF was marginally upregulated after 10 min. PMID: 26718740
- IL-29 directly induces RANKL expression in rheumatoid arthritis-fibroblasts like synoviocytes via MAPK signaling pathway. PMID: 26420479
- showed that silencing IFN-lambda1 in T/T cell line reduced basal IFN-stimulated gene expression and improved antiviral activity PMID: 26896692
- IFN-lambda-1 and interferon-gamma levels in systemic sclerosis patients were significantly higher than those in healthy individuals. PMID: 26057401
- this study failed to prove any significant association between polymorphisms in IL29 gene rs30461 or IL10 gene (-1082, -819 and -592) or cytokine haplotype and either response to therapy or severity of HCV infection in children. PMID: 25936570
- IL-29 can aggravate LPS/TLR4-mediated inflammation. PMID: 26278073
- NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation. PMID: 26353965
- the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells. PMID: 25756191
- Data suggest that naturally occurring iDVGs (immunostimulatory defective viral genomes) trigger robust host antiviral/innate immunity responses including/requiring up-regulation of IFNL1 and IFNB1 (interferon beta 1) in respiratory mucosa. PMID: 26336095
- there seems to be an inverse link between IFN-lambda and the severity of allergic asthma and allergic asthma exacerbations. PMID: 25592858
- Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B) and IFN-lambda4. PMID: 26194286
- Increased quantity of IL-29 in GCF and plasma of subjects with periodontitis suggests a role in pathogenesis of periodontitis and the SNP (rs30461) is not related to susceptibility to periodontitis in this population of Indian individuals. PMID: 25255471
- Severity of rhinovirus-induced asthma symptoms is inversely related to resolution IFNL1 expression. PMID: 25784275
- IL-29 is dysregulated in patients with rheumatoid arthritis (RA), which may contribute to the RA pathogenesis via inducing the production of proinflammatory cytokines, chemokines or matrix metalloproteinases in synovial fibroblasts. PMID: 23078630
- intranasal delivery of adenovirus expressing protein suppresses allergic asthma in a murine model PMID: 24819718
- IFN-lambda1-mediated IL-12 production in macrophages induces IFN-gamma production in human NK cells. PMID: 25316442
- data suggest that the p38alpha MAPK pathway is linked with RLR signaling pathways and regulates the expression of early IFN genes after RNA stimulation cooperatively with IRF3 and NF-kappaB to induce antiviral responses further PMID: 25473098
- Interferon lambda 1 induces antiviral response to herpes simplex virus 1 infection. PMID: 25518713
- These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection. PMID: 25355870
- Results showed no association between genotypes and alleles of IL28A, IL28B or IL29 polymorphisms and Hepatitis C virus infection. PMID: 24269996
- This study is the first to show the activation of a type III interferon response in low-risk human papillomavirus positive cervical cells and suggests that the lack of this response may be related to lesion progression. PMID: 24510368
- our data suggest that human but not mouse hepatocytes are responsive to IFN-lambda in vivo. PMID: 24498220
- protein expression is inhibited by hepatitis C virus PMID: 23529855
- IFNL1 expression in the human colon is transcriptionally regulated by ZEB-1, BLIMP-1, and NF-kappaB p50 and p65. PMID: 24140069
- These data suggest that T(Helper)17 cell-derived IL-29, which is absent in atopic dermatitis, mediates the robust antiviral state on psoriatic skin, and demonstrate a new function of T(H)17 cells. PMID: 24068736
- HBV infection upregulates IL-27 expression, which, in turn, stimulates IFN-lambda1 production. PMID: 24337382
- Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene. PMID: 24385435
- IL-32 levels during viral infection mediate antiviral effects by stimulating the expression of IFN-lambda1. PMID: 23729669
- IFN-lambdas can also directly affect T cells through inhibition of the T helper 2 cell (Th2) responses. IFN-lambdas have varying immunomodulatory functions under different physiological conditions PMID: 23207147
- RA patients that presented knee joint involvement displayed higher serum IFN-lambda1 than patients without knee joint involvement, suggesting that abnormally elevated IFN-lambda1 levels in RA can associate with knee joint disease. PMID: 23039206
- The viral infection induced both IFN-lambda1 promoter activity and that of the 3'-untranslated region (UTR), indicating that IFN-lambda1 expression is also regulated at the post-transcriptional level. PMID: 23150165
- IL-29 can regulate expression of protease activated receptors and tryptase- and trypsin-induced IL-4 production in mast cells. PMID: 23218741
- These data support a model of coordinated cell- and ligand-specific expression of types I and III interferon. PMID: 22249201
- After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients. PMID: 23151616
- IFN-alpha and IFN-lambda signal through distinct receptors, they induce expression of a common set of ISGs in hepatocytes. However, unlike IFN-alpha, IFN-lambda1 did not induce STAT activation or ISG expression by purified lymphocytes or monocytes PMID: 23258595
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亞細(xì)胞定位:Secreted.
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蛋白家族:Lambda interferon family
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