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  4. INPP5F Antibody, Biotin conjugated

INPP5F Antibody, Biotin conjugated

  • 中文名稱：
    INPP5F兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA896692ND01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) INPP5F Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    INPP5F antibody; KIAA0966 antibody; SAC2 antibody; MSTP007 antibody; MSTP047 antibody; Phosphatidylinositide phosphatase SAC2 antibody; EC 3.1.3.25 antibody; Inositol polyphosphate 5-phosphatase F antibody; Sac domain-containing inositol phosphatase 2 antibody; Sac domain-containing phosphoinositide 4-phosphatase 2 antibody; hSAC2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries.
  • 基因功能參考文獻：
    1. we identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival in Chronic lymphocytic leukemia PMID: 26430724
    2. These findings suggest that INPP5F is a potential tumor suppressor in gliomas via inhibition of STAT3 pathway, and that deregulation of INPP5F may lead to contribution to gliomagenesis. PMID: 25476455
    3. Sac2 colocalizes with early endosomal markers and is recruited to transferrin-containing vesicles during endocytic recycling. PMID: 25869669
    4. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. PMID: 19875726
  • 亞細胞定位：
    Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
  • 組織特異性：
    Ubiquitous. Highly expressed in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17054

    OMIM: 609389

    KEGG: hsa:22876

    STRING: 9606.ENSP00000354519

    UniGene: Hs.369755